Dissociation of Circulating Renin and Erythropoietin in Rats

Renin and erythropoietin activities were measured in the plasma of 110 rats exposed to various conditions designed to dissociate the two renal “hormones.” In acute experiments, intraperitoneal injection of polythiazide increased renin activity but did not change erythropoietin activity; exposure to...

Full description

Saved in:
Bibliographic Details
Published in:Circulation research 1968-01, Vol.22 (1), p.91-96
Main Authors: Donati, R M, Bourgoignie, J J, Kuhn, C, Gallagher, N I, Perry, H M
Format: Article
Language:English
Subjects:
Animals
Chlorides - pharmacology
Cobalt - pharmacology
Erythropoietin - metabolism
Hypoxia
Injections, Intraperitoneal
Oxygen Consumption
Polythiazide - pharmacology
Rats
Renin - metabolism
Sodium Chloride - administration & dosage
Space life sciences
Water-Electrolyte Balance
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Renin and erythropoietin activities were measured in the plasma of 110 rats exposed to various conditions designed to dissociate the two renal “hormones.” In acute experiments, intraperitoneal injection of polythiazide increased renin activity but did not change erythropoietin activity; exposure to low oxygen tension increased erythropoietin activity and caused an insignificant decrease in renin activity. In chronic experiments, salt restriction or the combination of salt loading and desoxycorticosterone for 2 weeks increased or decreased renin activity, respectively, without changing erythropoietin activity. The combination of chronic salt loading and acute hypoxia reduced renin activity and increased erythropoietin activity. In the final experiment, intraperitoneally injected cobaltous chloride acutely increased erythropoietin activity without markedly altering renin activity. Without contributing to the solution of the problem of the cell origin of erythropoietin, the present study clearly indicates that the secretion of renin and erythropoietin can be dissociated.
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.22.1.91