Urinary Hydroxyproline Excretion in Phosphate Depleted Rachitic Rats

THE increased output of hydroxyproline peptides in the urine of patients with osteomalacia 1 has been found to increase still further when the rickets are cured with phosphate 2 . Studies using 14 C-proline indicate that the hydroxyproline in the urine of growing rats is derived both from recently s...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1968-02, Vol.217 (5128), p.551-552
Main Authors: PARSONS, VICTOR, SELF, MALCOLM
Format: Article
Language:English
Subjects:
Animals
Calcium - blood
Carbon Dioxide - metabolism
Carbon Isotopes
Collagen - metabolism
Humanities and Social Sciences
Hydroxyproline - urine
letter
Male
multidisciplinary
Phosphates - blood
Phosphates - metabolism
Proline - metabolism
Rats
Rickets - urine
Science
Science (multidisciplinary)
Tibia - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:THE increased output of hydroxyproline peptides in the urine of patients with osteomalacia 1 has been found to increase still further when the rickets are cured with phosphate 2 . Studies using 14 C-proline indicate that the hydroxyproline in the urine of growing rats is derived both from recently synthesized soluble collagen and from the catabolism of the mature insoluble collagen fibres 3 . The experiments reported here were designed to discover whether the increased excretion of hydroxyproline in healing rickets comes from the synthesis of new collagen.
ISSN:0028-0836
1476-4687
DOI:10.1038/217551a0