Virus Containing Lymphocyte Cultures From Cancer Patients

Seven continuous cell cultures were established from 45 lymphoid tissue specimens from 43 cancer patients. All cultures were free-floating and appeared to be primarily lymphoblasts. Electron microscopic examination revealed herpesvirus-like particles in all the established cell lines and in one cell...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1967-10, Vol.39 (4), p.745-754
Main Authors: Jensen, Erling M., Korol, Wolodymyr, Dittmar, Susan L., Medrek, Theodore J.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cell Culture Techniques
Herpesviridae - isolation & purification
Humans
Leukemia - immunology
Leukemia - virology
Lymphocytes
Lymphoid Tissue - cytology
Lymphoma - immunology
Lymphoma - virology
Male
Microscopy, Electron
Middle Aged
Neoplasms - immunology
Neoplasms - virology
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Summary:Seven continuous cell cultures were established from 45 lymphoid tissue specimens from 43 cancer patients. All cultures were free-floating and appeared to be primarily lymphoblasts. Electron microscopic examination revealed herpesvirus-like particles in all the established cell lines and in one cell line that was maintained for only 1 month. The particles appeared identical to those observed in Burkitt's lymphoma and other lymphoma and leukemia cultures. In one instance virus particles were observed in the original tissue specimen before-cultivation. The virus particles were not infectious for several cell lines known to be susceptible to herpes simplex virus and other members of this group.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/39.4.745