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Virus Containing Lymphocyte Cultures From Cancer Patients
Seven continuous cell cultures were established from 45 lymphoid tissue specimens from 43 cancer patients. All cultures were free-floating and appeared to be primarily lymphoblasts. Electron microscopic examination revealed herpesvirus-like particles in all the established cell lines and in one cell...
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| Published in: | JNCI : Journal of the National Cancer Institute 1967-10, Vol.39 (4), p.745-754 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 754 |
| container_issue | 4 |
| container_start_page | 745 |
| container_title | JNCI : Journal of the National Cancer Institute |
| container_volume | 39 |
| creator | Jensen, Erling M. Korol, Wolodymyr Dittmar, Susan L. Medrek, Theodore J. |
| description | Seven continuous cell cultures were established from 45 lymphoid tissue specimens from 43 cancer patients. All cultures were free-floating and appeared to be primarily lymphoblasts. Electron microscopic examination revealed herpesvirus-like particles in all the established cell lines and in one cell line that was maintained for only 1 month. The particles appeared identical to those observed in Burkitt's lymphoma and other lymphoma and leukemia cultures. In one instance virus particles were observed in the original tissue specimen before-cultivation. The virus particles were not infectious for several cell lines known to be susceptible to herpes simplex virus and other members of this group. |
| doi_str_mv | 10.1093/jnci/39.4.745 |
| format | article |
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All cultures were free-floating and appeared to be primarily lymphoblasts. Electron microscopic examination revealed herpesvirus-like particles in all the established cell lines and in one cell line that was maintained for only 1 month. The particles appeared identical to those observed in Burkitt's lymphoma and other lymphoma and leukemia cultures. In one instance virus particles were observed in the original tissue specimen before-cultivation. 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All cultures were free-floating and appeared to be primarily lymphoblasts. Electron microscopic examination revealed herpesvirus-like particles in all the established cell lines and in one cell line that was maintained for only 1 month. The particles appeared identical to those observed in Burkitt's lymphoma and other lymphoma and leukemia cultures. In one instance virus particles were observed in the original tissue specimen before-cultivation. The virus particles were not infectious for several cell lines known to be susceptible to herpes simplex virus and other members of this group.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cell Culture Techniques</subject><subject>Herpesviridae - isolation & purification</subject><subject>Humans</subject><subject>Leukemia - immunology</subject><subject>Leukemia - virology</subject><subject>Lymphocytes</subject><subject>Lymphoid Tissue - cytology</subject><subject>Lymphoma - immunology</subject><subject>Lymphoma - virology</subject><subject>Male</subject><subject>Microscopy, Electron</subject><subject>Middle Aged</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - virology</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><recordid>eNo9j71PwzAUxC0EoqUwsqJMbGn9mdgjikiDVAmGUiEWy01ewCUfxXYk-t8TqYUb7g33uycdQrcEzwlWbLHrSrtgas7nKRdnaEp4gmNKsDhHU4xpGkuZ8gm68n6HRynKL9GEyIQyxfgUqY11g4-yvgvGdrb7iFaHdv_Zl4cAUTY0YXDgo9z1bZSZrgQXvZhgoQv-Gl3UpvFwc7oz9Jo_rrMiXj0vn7KHVWwpT0OsmIAtCIOhFrTkCgiRUFVbygzHNa1FpShOE0pqrGpVAlR0dFNXiZAgFGMzdH_8u3f99wA-6Nb6EprGdNAPXksuKSFJOoJ3J3DYtlDpvbOtcQf9N3YE4iNgfYCf_9y4Lz3WU6GLt3e9zrIiX7JCb9gv7Cll4g</recordid><startdate>196710</startdate><enddate>196710</enddate><creator>Jensen, Erling M.</creator><creator>Korol, Wolodymyr</creator><creator>Dittmar, Susan L.</creator><creator>Medrek, Theodore J.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>196710</creationdate><title>Virus Containing Lymphocyte Cultures From Cancer Patients</title><author>Jensen, Erling M. ; Korol, Wolodymyr ; Dittmar, Susan L. ; Medrek, Theodore J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i247t-935ebe5a0ef52c49e118eddb23a40f2f5d9207621f09f9ceed29ceafd658e5933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1967</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cell Culture Techniques</topic><topic>Herpesviridae - isolation & purification</topic><topic>Humans</topic><topic>Leukemia - immunology</topic><topic>Leukemia - virology</topic><topic>Lymphocytes</topic><topic>Lymphoid Tissue - cytology</topic><topic>Lymphoma - immunology</topic><topic>Lymphoma - virology</topic><topic>Male</topic><topic>Microscopy, Electron</topic><topic>Middle Aged</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jensen, Erling M.</creatorcontrib><creatorcontrib>Korol, Wolodymyr</creatorcontrib><creatorcontrib>Dittmar, Susan L.</creatorcontrib><creatorcontrib>Medrek, Theodore J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jensen, Erling M.</au><au>Korol, Wolodymyr</au><au>Dittmar, Susan L.</au><au>Medrek, Theodore J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Virus Containing Lymphocyte Cultures From Cancer Patients</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>Journal of the National Cancer Institute</addtitle><date>1967-10</date><risdate>1967</risdate><volume>39</volume><issue>4</issue><spage>745</spage><epage>754</epage><pages>745-754</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><abstract>Seven continuous cell cultures were established from 45 lymphoid tissue specimens from 43 cancer patients. 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| fulltext | fulltext |
| identifier | ISSN: 0027-8874 |
| ispartof | JNCI : Journal of the National Cancer Institute, 1967-10, Vol.39 (4), p.745-754 |
| issn | 0027-8874 1460-2105 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84821167 |
| source | Oxford University Press Archive |
| subjects | Adult Aged Aged, 80 and over Cell Culture Techniques Herpesviridae - isolation & purification Humans Leukemia - immunology Leukemia - virology Lymphocytes Lymphoid Tissue - cytology Lymphoma - immunology Lymphoma - virology Male Microscopy, Electron Middle Aged Neoplasms - immunology Neoplasms - virology |
| title | Virus Containing Lymphocyte Cultures From Cancer Patients |
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