Distribution of nestin protein: Immunohistochemical study in enteric plexus of rat duodenum

The intermediate nestin filament is expressed in neural stem cells, neuroectodermal tumors and various adult tissues under situations that reproduce developmental phases, e.g., physiological renewal of certain cell types, tissue regeneration, and healing or revascularization. In the human gastrointe...

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Bibliographic Details
Published in:Microscopy research and technique 2011-02, Vol.74 (2), p.148-152
Main Authors: Carmona, I. Cantarero, Luesma Bartolomé, M.J., Lavoie-Gagnon, C., Junquera Escribano, C.
Format: Article
Language:English
Subjects:
Animals
Duodenum - chemistry
Duodenum - innervation
Duodenum - metabolism
enteric glial cell
enteric nervous system
Female
glial fibrillary acidic protein
Immunohistochemistry
Intermediate Filament Proteins - analysis
Intermediate Filament Proteins - metabolism
Male
Myenteric Plexus - chemistry
Myenteric Plexus - metabolism
Nerve Tissue Proteins - analysis
Nerve Tissue Proteins - metabolism
Nestin
Neuroglia - metabolism
rat
Rats
Rats, Wistar
Submucous Plexus - chemistry
Submucous Plexus - metabolism
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Summary:The intermediate nestin filament is expressed in neural stem cells, neuroectodermal tumors and various adult tissues under situations that reproduce developmental phases, e.g., physiological renewal of certain cell types, tissue regeneration, and healing or revascularization. In the human gastrointestinal tract, nestin has been reported in glial cells and interstitial cells of Cajal. We examined by immunohistochemistry the appearance and distribution of nestin protein in enteric ganglia of rat duodenum. Through the myenteric and submucosal plexuses, a high number of nestin‐positive cells were visualized in this specie. The nestin‐positive cells were smaller and more numerous than enteric neurons. They were present both within and around ganglia. The results of this study suggest that the rat enteric glial cells (EGCs) are rich in nestin, a protein usually associated with dividing or migrating cells and the dynamic reorganization of nestin filaments during the cell cycle. EGCs could function as enteric stem cells. Microsc. Res. Tech. 74:148–152, 2011. © 2010 Wiley‐Liss, Inc.
ISSN:1059-910X
1097-0029
DOI:10.1002/jemt.20884