Expression and clinical relevance of uPA and ET-1 in non-small cell lung cancer

• Published in: Zhongguo fei ai za zhi 2011-01, Vol.14 (1), p.49-53
• Main Authors: Jiang, Yanyi, Liu, Yizhen, Shi, Zhizhou, Wang, Boshi, Shang, Li, Xu, Xin, Zhang, Shengzhou, Wang, Mingrong
• Format: Article
• Language: Chinese
• ISSN: 1999-6187
• DOI: 10.3779/j.issn.1009-3419.2011.01.10

BACKGROUND AND OBJECTIVEuPA and ET-1 proteins have been reported to be up-regulated in some of human cancers. The aim of this study is to investigate the alteration and clinical relevance of uPA and ET-1 protein levels in non-small cell lung cancer (NSCLC). METHODSExpressions of uPA and ET-1 protein were detected in 155 cases of NSCLC with tissue microarrays and immunohistochemistry (TMA-IHC) technique. The correlations between the alteration of the two proteins and clinicopathological parameters were analyzed. RESULTSNegative/weak, moderate and high expression of uPA were observed in 12.3%, 64.4% and 23.3% of squamous cell carcinomas, in 12.2%, 53.7% and 34.1% of adenocarcinomas, and in 12.3%, 58.7% and 29.0% of all cases. ET-1 presented negative/weak, moderate and high expression in 2.7%, 42.5% and 54.8% of squamous cell carcinomas, in 11.0%, 30.5% and 58.5% of adenocarcinomas, and in 7.1%, 36.1% and 56.8% of all cases. Simultaneously high expression of uPA and ET-1 were found in adenocarcinomas without lym