Expression and clinical relevance of uPA and ET-1 in non-small cell lung cancer

BACKGROUND AND OBJECTIVEuPA and ET-1 proteins have been reported to be up-regulated in some of human cancers. The aim of this study is to investigate the alteration and clinical relevance of uPA and ET-1 protein levels in non-small cell lung cancer (NSCLC). METHODSExpressions of uPA and ET-1 protein...

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Published in:Zhongguo fei ai za zhi 2011-01, Vol.14 (1), p.49-53
Main Authors: Jiang, Yanyi, Liu, Yizhen, Shi, Zhizhou, Wang, Boshi, Shang, Li, Xu, Xin, Zhang, Shengzhou, Wang, Mingrong
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container_title Zhongguo fei ai za zhi
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creator Jiang, Yanyi
Liu, Yizhen
Shi, Zhizhou
Wang, Boshi
Shang, Li
Xu, Xin
Zhang, Shengzhou
Wang, Mingrong
description BACKGROUND AND OBJECTIVEuPA and ET-1 proteins have been reported to be up-regulated in some of human cancers. The aim of this study is to investigate the alteration and clinical relevance of uPA and ET-1 protein levels in non-small cell lung cancer (NSCLC). METHODSExpressions of uPA and ET-1 protein were detected in 155 cases of NSCLC with tissue microarrays and immunohistochemistry (TMA-IHC) technique. The correlations between the alteration of the two proteins and clinicopathological parameters were analyzed. RESULTSNegative/weak, moderate and high expression of uPA were observed in 12.3%, 64.4% and 23.3% of squamous cell carcinomas, in 12.2%, 53.7% and 34.1% of adenocarcinomas, and in 12.3%, 58.7% and 29.0% of all cases. ET-1 presented negative/weak, moderate and high expression in 2.7%, 42.5% and 54.8% of squamous cell carcinomas, in 11.0%, 30.5% and 58.5% of adenocarcinomas, and in 7.1%, 36.1% and 56.8% of all cases. Simultaneously high expression of uPA and ET-1 were found in adenocarcinomas without lym
doi_str_mv 10.3779/j.issn.1009-3419.2011.01.10
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The aim of this study is to investigate the alteration and clinical relevance of uPA and ET-1 protein levels in non-small cell lung cancer (NSCLC). METHODSExpressions of uPA and ET-1 protein were detected in 155 cases of NSCLC with tissue microarrays and immunohistochemistry (TMA-IHC) technique. The correlations between the alteration of the two proteins and clinicopathological parameters were analyzed. RESULTSNegative/weak, moderate and high expression of uPA were observed in 12.3%, 64.4% and 23.3% of squamous cell carcinomas, in 12.2%, 53.7% and 34.1% of adenocarcinomas, and in 12.3%, 58.7% and 29.0% of all cases. ET-1 presented negative/weak, moderate and high expression in 2.7%, 42.5% and 54.8% of squamous cell carcinomas, in 11.0%, 30.5% and 58.5% of adenocarcinomas, and in 7.1%, 36.1% and 56.8% of all cases. 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title Expression and clinical relevance of uPA and ET-1 in non-small cell lung cancer
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