Specific Hydrogen Bonding of Barbiturates to Adenine Derivatives

Barbiturates form strong, specific hydrogen bonds with derivatives of adenine. This highly specific interaction which is more extensive than the hydrogen bonding between thymine (or uracil) derivatives and adenine derivatives may help to explain the different biological effects of barbiturates.

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Bibliographic Details
Published in:Nature (London) 1968-04, Vol.218 (5136), p.69-72
Main Authors: KYOGOKU, YOSHIMASA, LORD, R. C., RICH, ALEXANDER
Format: Article
Language:English
Subjects:
Adenine
Barbiturates
Chemical Phenomena
Chemistry
Humanities and Social Sciences
Infrared Rays
Models, Theoretical
multidisciplinary
Protein Binding
Science
Science (multidisciplinary)
Spectrum Analysis
Thymine
Uracil
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Description
Summary:Barbiturates form strong, specific hydrogen bonds with derivatives of adenine. This highly specific interaction which is more extensive than the hydrogen bonding between thymine (or uracil) derivatives and adenine derivatives may help to explain the different biological effects of barbiturates.
ISSN:0028-0836
1476-4687
DOI:10.1038/218069a0