Immunoglobulin Abnormalities in Gaucher's Disease Report of 16 Cases

Sera from ten of sixteen patients with known Gaucher’s disease were found to have immunoglobulin abnormalities. Of these, four patients had "monoclonal" IgG type K protein increases. The possible pathogenic roles of lipid accumulation and reticuloendothelial hyperplasia are discussed.

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Bibliographic Details
Published in:Blood 1968-05, Vol.31 (5), p.633-640
Main Authors: Pratt, Peter W., Estren, Solomon, Kochwa, Shaul
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Child
Female
gamma-Globulins
Gaucher Disease - immunology
Humans
Immunoelectrophoresis
Lymphatic Diseases - metabolism
Male
Middle Aged
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Description
Summary:Sera from ten of sixteen patients with known Gaucher’s disease were found to have immunoglobulin abnormalities. Of these, four patients had "monoclonal" IgG type K protein increases. The possible pathogenic roles of lipid accumulation and reticuloendothelial hyperplasia are discussed.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V31.5.633.633