Protein Synthesis in the Hippocampal Pyramidal Cells of Rats during a Behavioral Test

Protein synthesis was studied in the pyramidal nerve cells of the CA3 region in the hippocampus of rats during a behavioral test involving transfer of handedness. A new electrophoretic technique was used for separation of 10$^{-7}$ to 10$^{-9}$ gram of protein and radiometric determination of the va...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1968-03, Vol.159 (3821), p.1370-1373
Main Authors: Hydén, Holger, Lange, Paul W.
Format: Article
Language:English
Subjects:
Acrylic Resins
Animals
Behavior, Animal
Brain
Central nervous system
Electrophoresis
Enzymes
Functional Laterality
Gels
Hippocampus
Hippocampus - metabolism
Homogenization
Leucine - metabolism
Nerve Tissue Proteins - analysis
Nerve Tissue Proteins - biosynthesis
Neurons
Neurons - metabolism
Protein synthesis
Pyramidal cells
Rats
Transfer (Psychology)
Tritium
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Protein synthesis was studied in the pyramidal nerve cells of the CA3 region in the hippocampus of rats during a behavioral test involving transfer of handedness. A new electrophoretic technique was used for separation of 10$^{-7}$ to 10$^{-9}$ gram of protein and radiometric determination of the various protein fractions. After interventricular administration of $^{3}$H-leucine, protein synthesis of two fast-moving fractions was significantly higher bilaterally in the hippocampus of the trained rats. There was also a trend to lateralization of the highest protein synthesis to the learning side.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.159.3821.1370