Cigarette Smoking: Stimulatory Effect on Metabolism of 3,4-Benzpyrene by Enzymes in Human Placenta

The enzymatic hydroxylation of 3,4-benzpyrene was not detected in human placentas obtained after childbirth from nonsmokers, whereas this enzyme activity was present in placentas obtained from individuals who smoked cigarettes. The degree of induction of benzpyrene hydroxylase caused by cigarette sm...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1968-05, Vol.160 (3827), p.541-542
Main Authors: Welch, R. M., Harrison, Y. E., Conney, A. H., Poppers, P. J., Finster, M.
Format: Article
Language:English
Subjects:
Animals
Benzopyrenes - metabolism
Carcinogens
Cigarette smoking
Cigarettes
Dosage
Enzyme Induction
Enzymes
Female
Fetus
Gene induction
Humans
Metabolism
Mixed Function Oxygenases - metabolism
Placenta
Placenta - enzymology
Placenta - metabolism
Polycyclic compounds
Pregnancy
Pregnancy, Animal
Rats
Smoking
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Summary:The enzymatic hydroxylation of 3,4-benzpyrene was not detected in human placentas obtained after childbirth from nonsmokers, whereas this enzyme activity was present in placentas obtained from individuals who smoked cigarettes. The degree of induction of benzpyrene hydroxylase caused by cigarette smoking varied in different individuals. Treatment of pregnant rats with benzpyrene increased the activity of this hydroxylase in the placenta.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.160.3827.541