Tritiated digoxin excretion of patients following renal transplantation

Four patients with a single allografted kidney were given 1.0 mg of tritiated digoxin intravenously. Compared with patients with two normally functioning kidneys, these patients exhibited increased digoxin serum levels, modestly reduced renal excretion, and increased stool excretion of digoxin durin...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1968-05, Vol.37 (5), p.865-869
Main Authors: Doherty, J E, Flanigan, W J, Perkins, W H
Format: Article
Language:English
Subjects:
Adult
Blood Urea Nitrogen
Chromatography, Thin Layer
Digoxin - administration & dosage
Digoxin - analysis
Digoxin - blood
Digoxin - urine
Feces - analysis
Female
Heart Failure - metabolism
Humans
Injections, Intravenous
Kidney Function Tests
Kidney Transplantation
Male
Metabolic Clearance Rate
Middle Aged
Transplantation, Homologous
Tritium
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Description
Summary:Four patients with a single allografted kidney were given 1.0 mg of tritiated digoxin intravenously. Compared with patients with two normally functioning kidneys, these patients exhibited increased digoxin serum levels, modestly reduced renal excretion, and increased stool excretion of digoxin during a 7-day study. When administration of digoxin is indicated for a patient with a renal transplant, it may be necessary to reduce the dose even though renal function appears to be adequate.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.37.5.865