Antifungal activity of isothiocyanates and related compounds. 3. Derivatives of biphenyl, stilbene, azobenzene, and several polycondensed aromatic hydrocarbons

This paper presents the results of a study on the antifungal activity of isothiocyanates-derivatives of biphenyl (group "A"), of stilbene ("B"), of azobenzene and benzeneazonaphthalene ("C"), of naphthalene ("D"), and of further polycondensed aromatic hydrocar...

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Bibliographic Details
Published in:Applied microbiology 1968-04, Vol.16 (4), p.582-587
Main Authors: Drobnica, L, Zemanová, M, Nemec, P, Antos, K, Kristián, P, Martvon, A, Závodská, E
Format: Article
Language:English
Subjects:
Antifungal Agents - pharmacology
Aspergillus - drug effects
Azo Compounds - pharmacology
Biphenyl Compounds - pharmacology
Fungi - drug effects
Hydrocarbons - pharmacology
Naphthalenes - pharmacology
Penicillium - drug effects
Rhizopus - drug effects
Stilbenes - pharmacology
Thiocyanates - pharmacology
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Summary:This paper presents the results of a study on the antifungal activity of isothiocyanates-derivatives of biphenyl (group "A"), of stilbene ("B"), of azobenzene and benzeneazonaphthalene ("C"), of naphthalene ("D"), and of further polycondensed aromatic hydrocarbons ("E"). From a total of 48 investigated compounds, antifungal activity was observed only in A and D group compounds. B, C, and E group derivatives are extremely insoluble in water, and the molecules are very large; as a result, they probably cannot pass into spores or mycelium of fungi. Thus, the -NCS group cannot manifest its reactivity.
ISSN:0003-6919
DOI:10.1128/aem.16.4.582-587.1968