Effect of Gibberellic Acid on the Growth, Alkaloid Production, and VLB Content of Catharanthus Roseus

Catharanthus roseus, treated for 7 weeks with weekly doses of 100 mcg. of gibberellic acid (GA) and harvested biweekly, showed a significant increase in height and in stem dry weight. While GA treatment had a favorable effect on growth and did not affect the rate of flowering, it had an unfavorable...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1968-04, Vol.57 (4), p.589-593
Main Authors: Masoud, A.N., Sciuchetti, L.A., Farnsworth, N.R., Blomster, R.N., Meer, W.A.
Format: Article
Language:English
Subjects:
alkaloid content
Alkaloids - biosynthesis
Catharanthus roseus plants
Chlorophyll - metabolism
Chlorophyll content-leaves
Depression, Chemical
Gibberellic acid effect-growth
Gibberellic acid effect—growth, alkaloid content
Gibberellins - pharmacology
Plants, Medicinal - drug effects
Plants, Medicinal - growth & development
Solubility
Solvents
Stimulation, Chemical
Vinblastine - biosynthesis
Vincaleukoblastine content-gibberellic acid
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Summary:Catharanthus roseus, treated for 7 weeks with weekly doses of 100 mcg. of gibberellic acid (GA) and harvested biweekly, showed a significant increase in height and in stem dry weight. While GA treatment had a favorable effect on growth and did not affect the rate of flowering, it had an unfavorable effect on the concentration of total alkaloids in the plant organs. At final harvest the concentration of total alkaloids in the leaves was 55 percent of controls; that of the roots, 39 percent. Total alkaloid content per plant was greater than controls at the second harvest, but decreased at the fourth harvest. Detectable quantities of vincaleukoblastine (VLB) were not found in the stems or roots of both treated and untreated groups, but an increase of VLB concentration was noted in the leaves of the treated group. Gibberellic acid treatment had no affect on chlorophyll content, but markedly reduced the petroleum ether and ether extracts of plant organs.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600570408