Determination of Free Salicylic Acid in Buffered Aspirin Tablets

Aspirin and free saliyclic acid are quantitatively released from buffered aspirin tablets, with a negligible degree of hydrolysis of aspirin, by briefly wetting the sample with 98—100 percent formic acid, followed by immediate dilution with chloroform. The salicylic acid is isolated and determined a...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1968-04, Vol.57 (4), p.631-633
Main Authors: Levine, Joseph, Weber, John D.
Format: Article
Language:English
Subjects:
Aspirin - analysis
Aspirin tablets
Aspirin tablets, buffered—free salicylic acid
buffered-free salicylic acid
Buffers
Chloroform diluent
Chromatography
Column chromatography-separation
Drug Stability
Formic acid-preanalysis sample wetting
free-analysis
Hydrolysis rate-aspirin
Salicylates - analysis
Salicylic acid
Salicylic acid, free—analysis
Silicon Dioxide
Solubility
Spectrophotometry
Tablets - analysis
Ultraviolet Rays
UV spectrophotometry-identity
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Description
Summary:Aspirin and free saliyclic acid are quantitatively released from buffered aspirin tablets, with a negligible degree of hydrolysis of aspirin, by briefly wetting the sample with 98—100 percent formic acid, followed by immediate dilution with chloroform. The salicylic acid is isolated and determined as previously described.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600570418