Synthesis and Properties of the Antileukemic Agent 5(or 4)-[3,3-Bis(2-chloroethyl)-1-triazeno]imidazole-4(or 5)-carboxamide

The antileukemic agent 5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4 (or 5)-carboxamide (II, NSC-82196) is an unstable compound that is easily convertible to an isomeric transformation product. By taking appropriate precautions, however, the triazene may be prepared in good yield, with very...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1968-01, Vol.57 (1), p.83-86
Main Authors: Shealy, Y.Fulmer, Krauth, Charles A., Holum, Lee B., Fitzgibbon, William E.
Format: Article
Language:English
Subjects:
3-Bis(2-chloroethyl)-1-triazeno]-imidazole-4(or 5)-carboxamide
5(or 4)-
5(or 4)-[3,3-Bis(2-chloroethyl)-1-triazeno]-imidazole-4(or 5)-carboxamide,—syntheses
Antileukemic agent
Antineoplastic Agents - chemical synthesis
Chemistry, Pharmaceutical
Chromatography, Thin Layer
IR spectrophotometry-structure
Spectrophotometry
Spectrum Analysis
syntheses
TLC separation
Triazene transformation product
UV spectrophotometry-structure
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Description
Summary:The antileukemic agent 5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4 (or 5)-carboxamide (II, NSC-82196) is an unstable compound that is easily convertible to an isomeric transformation product. By taking appropriate precautions, however, the triazene may be prepared in good yield, with very little of the transformation product as contaminant, and may be stored for long periods at low temperatures. The quality of specimens of II may be estimated from its infrared spectrum and that of its transformation product.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600570116