Familial Prevalence of Celiac Disease

Serological screening enables us to detect patients of celiac disease (CD) before they develop serious complications. This study was planned to assess the prevalence of CD in the family members of index cases by serological screening. A prospective study was conducted on 50 children diagnosed to be...

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Bibliographic Details
Published in:Journal of tropical pediatrics (1980) 2011-02, Vol.57 (1), p.45-50
Main Authors: BABU RAM THAPA, RAWAL, Pawan, SAPRA, Bharat, VAIPHEI, Kim, CHANDER KANWAL NAIN, SINGH, Kartar
Format: Article
Language:English
Subjects:
Adolescent
Adult
Autoantibodies - blood
Biological and medical sciences
Biomarkers - analysis
Biopsy
Celiac Disease - diagnosis
Celiac Disease - epidemiology
Celiac Disease - genetics
Celiac Disease - immunology
Child
Child, Preschool
Duodenoscopy
Duodenum - pathology
Enzyme-Linked Immunosorbent Assay
Family
Female
Fluorescent Antibody Technique, Indirect
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Genetic Predisposition to Disease
Gliadin - immunology
Humans
Immunoglobulin A - blood
Immunoglobulin G - blood
India - epidemiology
Male
Mass Screening - methods
Medical sciences
Middle Aged
Other diseases. Semiology
Predictive Value of Tests
Prevalence
Prospective Studies
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Transglutaminases - immunology
Young Adult
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Summary:Serological screening enables us to detect patients of celiac disease (CD) before they develop serious complications. This study was planned to assess the prevalence of CD in the family members of index cases by serological screening. A prospective study was conducted on 50 children diagnosed to be having CD. Serological screening of the family members of index cases was done and those showing positivity for the screening tests were further subjected to endoscopic duodenal biopsy for histopathological examination. A total of 164 members of 50 celiac families were initially screened for antibodies. Antibody picked up 32.9% by IgG anti-gliadin (AGA), 20.7% by endomysial antibody, 19.5% by tissue transglutaminase and 14.6% IgA AGA as seropositive for CD. Endoscopic findings characteristics for CD were present in only eight family members. Family members of CD cases represent potential cases of CD.
ISSN:0142-6338
1465-3664
DOI:10.1093/tropej/fmq041