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Familial Prevalence of Celiac Disease
Serological screening enables us to detect patients of celiac disease (CD) before they develop serious complications. This study was planned to assess the prevalence of CD in the family members of index cases by serological screening. A prospective study was conducted on 50 children diagnosed to be...
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| Published in: | Journal of tropical pediatrics (1980) 2011-02, Vol.57 (1), p.45-50 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c361t-39595e10a4ef23ff937bcfb7bcc528c87eccbd5bc4a98f7304306d3c273d0f4a3 |
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| cites | cdi_FETCH-LOGICAL-c361t-39595e10a4ef23ff937bcfb7bcc528c87eccbd5bc4a98f7304306d3c273d0f4a3 |
| container_end_page | 50 |
| container_issue | 1 |
| container_start_page | 45 |
| container_title | Journal of tropical pediatrics (1980) |
| container_volume | 57 |
| creator | BABU RAM THAPA RAWAL, Pawan SAPRA, Bharat VAIPHEI, Kim CHANDER KANWAL NAIN SINGH, Kartar |
| description | Serological screening enables us to detect patients of celiac disease (CD) before they develop serious complications. This study was planned to assess the prevalence of CD in the family members of index cases by serological screening.
A prospective study was conducted on 50 children diagnosed to be having CD. Serological screening of the family members of index cases was done and those showing positivity for the screening tests were further subjected to endoscopic duodenal biopsy for histopathological examination.
A total of 164 members of 50 celiac families were initially screened for antibodies. Antibody picked up 32.9% by IgG anti-gliadin (AGA), 20.7% by endomysial antibody, 19.5% by tissue transglutaminase and 14.6% IgA AGA as seropositive for CD. Endoscopic findings characteristics for CD were present in only eight family members.
Family members of CD cases represent potential cases of CD. |
| doi_str_mv | 10.1093/tropej/fmq041 |
| format | article |
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A prospective study was conducted on 50 children diagnosed to be having CD. Serological screening of the family members of index cases was done and those showing positivity for the screening tests were further subjected to endoscopic duodenal biopsy for histopathological examination.
A total of 164 members of 50 celiac families were initially screened for antibodies. Antibody picked up 32.9% by IgG anti-gliadin (AGA), 20.7% by endomysial antibody, 19.5% by tissue transglutaminase and 14.6% IgA AGA as seropositive for CD. Endoscopic findings characteristics for CD were present in only eight family members.
Family members of CD cases represent potential cases of CD.</description><identifier>ISSN: 0142-6338</identifier><identifier>EISSN: 1465-3664</identifier><identifier>DOI: 10.1093/tropej/fmq041</identifier><identifier>PMID: 20554512</identifier><identifier>CODEN: JTRPAO</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adolescent ; Adult ; Autoantibodies - blood ; Biological and medical sciences ; Biomarkers - analysis ; Biopsy ; Celiac Disease - diagnosis ; Celiac Disease - epidemiology ; Celiac Disease - genetics ; Celiac Disease - immunology ; Child ; Child, Preschool ; Duodenoscopy ; Duodenum - pathology ; Enzyme-Linked Immunosorbent Assay ; Family ; Female ; Fluorescent Antibody Technique, Indirect ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Genetic Predisposition to Disease ; Gliadin - immunology ; Humans ; Immunoglobulin A - blood ; Immunoglobulin G - blood ; India - epidemiology ; Male ; Mass Screening - methods ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Predictive Value of Tests ; Prevalence ; Prospective Studies ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Transglutaminases - immunology ; Young Adult</subject><ispartof>Journal of tropical pediatrics (1980), 2011-02, Vol.57 (1), p.45-50</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-39595e10a4ef23ff937bcfb7bcc528c87eccbd5bc4a98f7304306d3c273d0f4a3</citedby><cites>FETCH-LOGICAL-c361t-39595e10a4ef23ff937bcfb7bcc528c87eccbd5bc4a98f7304306d3c273d0f4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23932952$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20554512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BABU RAM THAPA</creatorcontrib><creatorcontrib>RAWAL, Pawan</creatorcontrib><creatorcontrib>SAPRA, Bharat</creatorcontrib><creatorcontrib>VAIPHEI, Kim</creatorcontrib><creatorcontrib>CHANDER KANWAL NAIN</creatorcontrib><creatorcontrib>SINGH, Kartar</creatorcontrib><title>Familial Prevalence of Celiac Disease</title><title>Journal of tropical pediatrics (1980)</title><addtitle>J Trop Pediatr</addtitle><description>Serological screening enables us to detect patients of celiac disease (CD) before they develop serious complications. This study was planned to assess the prevalence of CD in the family members of index cases by serological screening.
A prospective study was conducted on 50 children diagnosed to be having CD. Serological screening of the family members of index cases was done and those showing positivity for the screening tests were further subjected to endoscopic duodenal biopsy for histopathological examination.
A total of 164 members of 50 celiac families were initially screened for antibodies. Antibody picked up 32.9% by IgG anti-gliadin (AGA), 20.7% by endomysial antibody, 19.5% by tissue transglutaminase and 14.6% IgA AGA as seropositive for CD. Endoscopic findings characteristics for CD were present in only eight family members.
Family members of CD cases represent potential cases of CD.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Biopsy</subject><subject>Celiac Disease - diagnosis</subject><subject>Celiac Disease - epidemiology</subject><subject>Celiac Disease - genetics</subject><subject>Celiac Disease - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Duodenoscopy</subject><subject>Duodenum - pathology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Family</subject><subject>Female</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Genetic Predisposition to Disease</subject><subject>Gliadin - immunology</subject><subject>Humans</subject><subject>Immunoglobulin A - blood</subject><subject>Immunoglobulin G - blood</subject><subject>India - epidemiology</subject><subject>Male</subject><subject>Mass Screening - methods</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Predictive Value of Tests</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Transglutaminases - immunology</subject><subject>Young Adult</subject><issn>0142-6338</issn><issn>1465-3664</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNpF0EFLwzAUwPEgipvTo1fpZXiqS_KSNDnKdCoM9KDnkKYv0NGuW9IJfnsrnXp5Dx4_3uFPyDWjd4waWPSx2-FmEdo9FeyETJlQMgelxCmZUiZ4rgD0hFyktKGUci3EOZlwKqWQjE_JfOXauqldk71F_HQNbj1mXciWOBx99lAndAkvyVlwTcKr456Rj9Xj-_I5X78-vSzv17kHxfocjDQSGXUCA4cQDBSlD-UwvOTa6wK9LytZeuGMDgVQAVRV4HkBFQ3CwYzcjn93sdsfMPW2rZPHpnFb7A7JaqGV1pSLQeaj9LFLKWKwu1i3Ln5ZRu1PGDuGsWOYwd8cPx_KFqs__VtiAPMjcMm7JkS39XX6d2CAG8nhGymmbGc</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>BABU RAM THAPA</creator><creator>RAWAL, Pawan</creator><creator>SAPRA, Bharat</creator><creator>VAIPHEI, Kim</creator><creator>CHANDER KANWAL NAIN</creator><creator>SINGH, Kartar</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110201</creationdate><title>Familial Prevalence of Celiac Disease</title><author>BABU RAM THAPA ; RAWAL, Pawan ; SAPRA, Bharat ; VAIPHEI, Kim ; CHANDER KANWAL NAIN ; SINGH, Kartar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-39595e10a4ef23ff937bcfb7bcc528c87eccbd5bc4a98f7304306d3c273d0f4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Biopsy</topic><topic>Celiac Disease - diagnosis</topic><topic>Celiac Disease - epidemiology</topic><topic>Celiac Disease - genetics</topic><topic>Celiac Disease - immunology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Duodenoscopy</topic><topic>Duodenum - pathology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Family</topic><topic>Female</topic><topic>Fluorescent Antibody Technique, Indirect</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General aspects</topic><topic>Genetic Predisposition to Disease</topic><topic>Gliadin - immunology</topic><topic>Humans</topic><topic>Immunoglobulin A - blood</topic><topic>Immunoglobulin G - blood</topic><topic>India - epidemiology</topic><topic>Male</topic><topic>Mass Screening - methods</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Predictive Value of Tests</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Transglutaminases - immunology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BABU RAM THAPA</creatorcontrib><creatorcontrib>RAWAL, Pawan</creatorcontrib><creatorcontrib>SAPRA, Bharat</creatorcontrib><creatorcontrib>VAIPHEI, Kim</creatorcontrib><creatorcontrib>CHANDER KANWAL NAIN</creatorcontrib><creatorcontrib>SINGH, Kartar</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of tropical pediatrics (1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BABU RAM THAPA</au><au>RAWAL, Pawan</au><au>SAPRA, Bharat</au><au>VAIPHEI, Kim</au><au>CHANDER KANWAL NAIN</au><au>SINGH, Kartar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Familial Prevalence of Celiac Disease</atitle><jtitle>Journal of tropical pediatrics (1980)</jtitle><addtitle>J Trop Pediatr</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>57</volume><issue>1</issue><spage>45</spage><epage>50</epage><pages>45-50</pages><issn>0142-6338</issn><eissn>1465-3664</eissn><coden>JTRPAO</coden><abstract>Serological screening enables us to detect patients of celiac disease (CD) before they develop serious complications. This study was planned to assess the prevalence of CD in the family members of index cases by serological screening.
A prospective study was conducted on 50 children diagnosed to be having CD. Serological screening of the family members of index cases was done and those showing positivity for the screening tests were further subjected to endoscopic duodenal biopsy for histopathological examination.
A total of 164 members of 50 celiac families were initially screened for antibodies. Antibody picked up 32.9% by IgG anti-gliadin (AGA), 20.7% by endomysial antibody, 19.5% by tissue transglutaminase and 14.6% IgA AGA as seropositive for CD. Endoscopic findings characteristics for CD were present in only eight family members.
Family members of CD cases represent potential cases of CD.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>20554512</pmid><doi>10.1093/tropej/fmq041</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0142-6338 |
| ispartof | Journal of tropical pediatrics (1980), 2011-02, Vol.57 (1), p.45-50 |
| issn | 0142-6338 1465-3664 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_848688024 |
| source | Oxford Journals Online |
| subjects | Adolescent Adult Autoantibodies - blood Biological and medical sciences Biomarkers - analysis Biopsy Celiac Disease - diagnosis Celiac Disease - epidemiology Celiac Disease - genetics Celiac Disease - immunology Child Child, Preschool Duodenoscopy Duodenum - pathology Enzyme-Linked Immunosorbent Assay Family Female Fluorescent Antibody Technique, Indirect Gastroenterology. Liver. Pancreas. Abdomen General aspects Genetic Predisposition to Disease Gliadin - immunology Humans Immunoglobulin A - blood Immunoglobulin G - blood India - epidemiology Male Mass Screening - methods Medical sciences Middle Aged Other diseases. Semiology Predictive Value of Tests Prevalence Prospective Studies Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Transglutaminases - immunology Young Adult |
| title | Familial Prevalence of Celiac Disease |
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