Hypersensitivity: Specific Immunologic Suppression of the Delayed Type

Delayed-type cutaneous hypersensitivity to sheep erythrocytes was induced in rats by intradermal injection of the antigen mixed with Freund's adjuvant; hypersensitivity was sustained by weekly injections. Either passive immunization with rat antiserum to sheep erythrocytes or intravenous inject...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1968-06, Vol.160 (3835), p.1465-1467
Main Authors: Axelrad, Michael, Rowley, Donald A.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antigens
Antiserum
Delayed hypersensitivity
Dosage
Erythrocytes
Erythrocytes - immunology
Female
Freund's Adjuvant
Hypersensitivity
Hypersensitivity, Delayed
Immunity, Maternally-Acquired
Immunization
Passive immunization
Rats
Sensitization
Sheep
Transplantation immunology
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Summary:Delayed-type cutaneous hypersensitivity to sheep erythrocytes was induced in rats by intradermal injection of the antigen mixed with Freund's adjuvant; hypersensitivity was sustained by weekly injections. Either passive immunization with rat antiserum to sheep erythrocytes or intravenous injection of sheep erythrocytes partially suppressed induction of hypersensitivity; these procedures used together specifically and completely suppressed induction of hypersensitivity. Complete suppression was sustained by antigen given intravenously before each weekly injection of the mixture of antigen and adjuvant. These findings provide the rational basis of a simple method for prolonging survival of allografts with only the biological agents, antigen and antibody, of the immunological response.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.160.3835.1465