Multiple mucosal neuromas, pheochromocytoma and medullary carcinoma of the thyroid—a syndrome

An analysis of 17 cases of the syndrome of multiple mucosal neuromas, pheochromocytoma and medullary carcinoma of the thyroid is presented and its relationship to similar syndromes discussed. The mucosal neuromas primarily involve the lips, anterior tongue, conjunctiva and nasal and laryngeal mucosa...

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Bibliographic Details
Published in:Cancer 1968-08, Vol.22 (2), p.293-299
Main Authors: Gorlin, Robert J., Sedano, Heddie O., Vickers, Robert A., Červenka, Jaroslav
Format: Article
Language:English
Subjects:
Carcinoma - genetics
Female
Humans
Male
Mouth Neoplasms - genetics
Neoplasms, Multiple Primary - genetics
Neuroma - genetics
Pheochromocytoma - genetics
Thyroid Neoplasms - genetics
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Summary:An analysis of 17 cases of the syndrome of multiple mucosal neuromas, pheochromocytoma and medullary carcinoma of the thyroid is presented and its relationship to similar syndromes discussed. The mucosal neuromas primarily involve the lips, anterior tongue, conjunctiva and nasal and laryngeal mucosa. Medullated corneal nerve fibers traverse the cornea and anastomose in the pupillary area. A Marfanoid build and diverticulosis may be associated findings.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(196808)22:2<293::AID-CNCR2820220206>3.0.CO;2-R