Microglobulinaemia in Renal Failure

IMPAIRMENT of renal function is associated with body retention of certain simple organic compounds such as urea, creatinine and uric acid. We describe here the occurrence of markedly increased concentrations of a low molecular weight protein in the sera of patients with renal failure. Neither the me...

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Bibliographic Details
Published in:Nature (London) 1968-05, Vol.218 (5141), p.598-599
Main Authors: BERNIER, GEORGE M., COHEN, RICHARD J., CONRAD, MARCEL E.
Format: Article
Language:English
Subjects:
Animals
Beta-Globulins - blood
Beta-Globulins - urine
Blood Protein Disorders - etiology
Blood Protein Electrophoresis
Creatinine - blood
Humanities and Social Sciences
Humans
Immunodiffusion
Kidney Failure, Chronic - complications
letter
multidisciplinary
Rabbits
Science
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Summary:IMPAIRMENT of renal function is associated with body retention of certain simple organic compounds such as urea, creatinine and uric acid. We describe here the occurrence of markedly increased concentrations of a low molecular weight protein in the sera of patients with renal failure. Neither the mechanism nor the physiological consequences of this abnormality are evident, but a defect in the renal catabolism of the protein may be responsible for this selective hyperproteinaemia.
ISSN:0028-0836
1476-4687
DOI:10.1038/218598a0