Actomyosin-Like Protein Isolated from Mammalian Brain

A protein with characteristics similar to actomyosin has been isolated from whole brain of rat and cat. It is soluble in 0.6 molar potassium chloride and insoluble in 0.1 molar potassium chloride. It superprecipitates with magnesium ions and adenosine triphosphate. It has adenosine triphosphatase ac...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1968-07, Vol.161 (3837), p.170-171
Main Authors: Puszkin, S., Berl, S., Puszkin, Elena, Clarke, D. D.
Format: Article
Language:English
Subjects:
Adenosine triphosphatases
Adenosine Triphosphatases - antagonists & inhibitors
Adenosine Triphosphatases - metabolism
Adenosine Triphosphate - metabolism
Animals
Biochemistry
Brain Chemistry
Calcium - pharmacology
Cations
Cats
Cell membranes
Chemical Precipitation
Chloromercuribenzoates - pharmacology
Contractile proteins
Depression, Chemical
Enzyme activity
Enzymes
Grants
Ions
Magnesium - pharmacology
Muscle Proteins
Nerve Tissue Proteins - analysis
Organomercury Compounds - pharmacology
Parkinson disease
Potassium Chloride - pharmacology
Rats
Stimulation, Chemical
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Summary:A protein with characteristics similar to actomyosin has been isolated from whole brain of rat and cat. It is soluble in 0.6 molar potassium chloride and insoluble in 0.1 molar potassium chloride. It superprecipitates with magnesium ions and adenosine triphosphate. It has adenosine triphosphatase activity stimulated by either magnesium or calcium ions. Both superprecipitation and adenosine triphosphatase activity are inhibited by p-chloromercuribenzoate and Mersalyl but not by ouabain.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.161.3837.170