Juxtaglomerular Cell Tumor of the Kidney: Case Report and Differential Diagnosis With Emphasis on Pathologic and Cytopathologic Features

This study presents a case of juxtaglomerular cell tumor (JCT) in a 12-year-old girl with hypertension. Fine needle aspirate (FNA) cytology demonstrated a neoplasm with features of a papillary carcinoma, prompting a right radical nephrectomy. Histological examination revealed solid sheets of round e...

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Published in:International journal of surgical pathology 2011-02, Vol.19 (1), p.93-98
Main Authors: Méndez, Gonzalo P., Klock, Clóvis, Nosé, Vânia
Format: Article
Language:English
Subjects:
Carcinoma, Papillary - pathology
Carcinoma, Papillary - secretion
Carcinoma, Papillary - surgery
Carcinoma, Renal Cell - pathology
Child
Diagnosis, Differential
Female
Humans
Immunohistochemistry
Juxtaglomerular Apparatus - pathology
Juxtaglomerular Apparatus - secretion
Juxtaglomerular Apparatus - surgery
Kidney Neoplasms - pathology
Kidney Neoplasms - secretion
Kidney Neoplasms - surgery
Microscopy, Electron
Nephrectomy
Renin - secretion
Wilms Tumor - pathology
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description This study presents a case of juxtaglomerular cell tumor (JCT) in a 12-year-old girl with hypertension. Fine needle aspirate (FNA) cytology demonstrated a neoplasm with features of a papillary carcinoma, prompting a right radical nephrectomy. Histological examination revealed solid sheets of round epithelioid cells with eosinophilic granular cytoplasm, and distinct cell borders in a background of widespread hemorrhage. Electron microscopy revealed cytoplasmic renin granules. The differential diagnosis of a renal mass in a young patient with hypertension includes JCT, Wilm’s tumor, and renal cell carcinoma, which may produce renin. The renin granules detected by electron microscopy are characteristic of JCT, and the diagnosis is confirmed by ultrastructural study. FNA cytology is not sensitive enough for the diagnosis of JCT and its results must be carefully interpreted.
doi_str_mv 10.1177/1066896908329413
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subjects Carcinoma, Papillary - pathology
Carcinoma, Papillary - secretion
Carcinoma, Papillary - surgery
Carcinoma, Renal Cell - pathology
Child
Diagnosis, Differential
Female
Humans
Immunohistochemistry
Juxtaglomerular Apparatus - pathology
Juxtaglomerular Apparatus - secretion
Juxtaglomerular Apparatus - surgery
Kidney Neoplasms - pathology
Kidney Neoplasms - secretion
Kidney Neoplasms - surgery
Microscopy, Electron
Nephrectomy
Renin - secretion
Wilms Tumor - pathology
title Juxtaglomerular Cell Tumor of the Kidney: Case Report and Differential Diagnosis With Emphasis on Pathologic and Cytopathologic Features
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