Effects of calcium, magnesium, low-dose aspirin and low-molecular-weight heparin on the release of PP13 from placental explants

Abstract Background Preeclampsia is one of the leading causes for maternal and fetal morbidity. Attempts to prevent preeclampsia have already been made using low-dose aspirin, low-molecular-weight heparin (LMWH), and calcium supplementation. Magnesium sulphate is used at the time of disease to preve...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2011-02, Vol.32, p.S55-S64
Main Authors: Grimpel, Y.-I, Kivity, V, Cohen, A, Meiri, H, Sammar, M, Gonen, R, Huppertz, B
Format: Article
Language:English
Subjects:
Adult
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Anticoagulants - pharmacology
Aspirin
Aspirin - pharmacology
Calcium
Calcium - pharmacology
Cells, Cultured
Female
Galectins - secretion
Gestational Age
Heparin, Low-Molecular-Weight - pharmacology
Humans
Internal Medicine
Low-molecular-weight-heparin
Magnesium - pharmacology
Magnesium placenta
Obstetrics and Gynecology
Organ Culture Techniques
Placenta - drug effects
Placenta - secretion
PP13
Preeclampsia
Pregnancy
Pregnancy Proteins - secretion
Young Adult
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Summary:Abstract Background Preeclampsia is one of the leading causes for maternal and fetal morbidity. Attempts to prevent preeclampsia have already been made using low-dose aspirin, low-molecular-weight heparin (LMWH), and calcium supplementation. Magnesium sulphate is used at the time of disease to prevent eclampsia. Here we investigated the effect of these agents on PP13 release from placental explants. Methods Placentas harvested after C-section of term or preterm control and preeclampsia cases or first trimester terminations were used to obtain explants. Explants were incubated for 24 h with/without respective agents, harvested, weighed and subjected to PP13 determination in the culture medium and the explant. LDH was used to determine viability. Dose response curves were obtained for each drug. P  
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2010.11.019