A Contemporary Population-Based Assessment of the Rate of Lymph Node Dissection for Penile Carcinoma

Background The adherence rate to National Cancer Institute (NCI) recommendations regarding inguinal lymph nodes dissection (ILND) in high grade T1 (G3T1) and T2-4 squamous cell carcinoma of the penis (SCCP) is not known. We assessed ILND rates in a North American cohort. Materials and Methods The 17...

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Bibliographic Details
Published in:Annals of surgical oncology 2011-02, Vol.18 (2), p.439-446
Main Authors: Thuret, Rodolphe, Sun, Maxine, Lughezzani, Giovanni, Budaus, Lars, Liberman, Daniel, Abdollah, Firas, Morgan, Monica, Johal, Rupinder, Jeldres, Claudio, Latour, Mathieu, Shariat, Shahrokh F., Iborra, François, Guiter, Jacques, Patard, Jean-Jacques, Perrotte, Paul, Karakiewicz, Pierre I.
Format: Article
Language:English
Subjects:
Aged
Carcinoma, Squamous Cell - epidemiology
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Follow-Up Studies
Humans
Lymph Node Excision - standards
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Penile Neoplasms - epidemiology
Penile Neoplasms - pathology
Penile Neoplasms - surgery
Population Surveillance
Prognosis
SEER Program
Sentinel Lymph Node Biopsy - standards
Surgery
Surgical Oncology
Survival Rate
United States - epidemiology
Urologic Oncology
Urologic Surgical Procedures, Male
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Summary:Background The adherence rate to National Cancer Institute (NCI) recommendations regarding inguinal lymph nodes dissection (ILND) in high grade T1 (G3T1) and T2-4 squamous cell carcinoma of the penis (SCCP) is not known. We assessed ILND rates in a North American cohort. Materials and Methods The 17 registries of the Surveillance, Epidemiology, and End Results (SEER) database included 868 patients with SCCP, diagnosed between 1988 and 2006. Analyses consisted of univariable and multivariable logistic regression models. Results Overall, 27.6% of patients underwent an ILND. ILND rates were directly proportional with T stage: 19.0%, 30.5%, 30.6%, and 32.6% for, respectively, G3T1, T2, T3, and T4 SCCP (chi-square trend, P  = 0.01). ILND rates also increased over time and were 19.3, 27.3, 30.7, and 30.8% for respectively, 1988–1995, 1996–2000, 2001–2003, and 2004–2006 periods (chi-square trend, P  = 0.03). Finally, ILND rates decreased with patient age and were 42.6, 33.2, 24.7, and 7.3% for, respectively, patients aged ≤57, 58–68, 69–78 and ≥79 years of age (chi-square trend, P  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-010-1315-6