Lesch-Nyhan syndrome treated from the early neonatal period

An infant with the Lesch-Nyhan Syndrome was treated from 4 days of life with allopurinol. Such therapy was not successful in preventing the appearance of mental retardation, spasticity, and self-mutilation, which are the hallmarks of this disease.

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Bibliographic Details
Published in:Pediatrics (Evanston) 1968-08, Vol.42 (2), p.357-359
Main Authors: Marks, J F, Baum, J, Keele, D K, Kay, J L, MacFarlen, A
Format: Article
Language:English
Subjects:
Allopurinol - therapeutic use
Humans
Infant
Infant, Newborn
Intellectual Disability - complications
Male
Metabolism, Inborn Errors - drug therapy
Muscle Cramp - complications
Self Mutilation - complications
Uric Acid - urine
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Description
Summary:An infant with the Lesch-Nyhan Syndrome was treated from 4 days of life with allopurinol. Such therapy was not successful in preventing the appearance of mental retardation, spasticity, and self-mutilation, which are the hallmarks of this disease.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.42.2.357