Prostaglandins released by the Spleen

Experiments with dogs have shown that both prostaglandin E 2 and F 2α are released when the spleen is contracted by nerve stimulation or by adrenaline. The prostaglandins are not released from the nerves, but derive from smooth muscle cells or other cells with similar adrenergic innervation. The pro...

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Bibliographic Details
Published in:Nature (London) 1968-06, Vol.218 (5147), p.1135-1140
Main Authors: VANE, J. R, WYLLIE, J. H, GILMORE, N
Format: Article
Language:English
Subjects:
Animals
Chromatography, Thin Layer
Dogs
Electric Stimulation
Epinephrine - pharmacology
Female
Hemoglobins
Humanities and Social Sciences
Male
multidisciplinary
Muscle Contraction
Muscles - innervation
Neurons - metabolism
Organ Size
Prostaglandins - metabolism
Science
Science (multidisciplinary)
Spleen - metabolism
Spleen - physiology
Stimulation, Chemical
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Description
Summary:Experiments with dogs have shown that both prostaglandin E 2 and F 2α are released when the spleen is contracted by nerve stimulation or by adrenaline. The prostaglandins are not released from the nerves, but derive from smooth muscle cells or other cells with similar adrenergic innervation. The prostaglandin release is not the cause of splenic contraction.
ISSN:0028-0836
1476-4687
DOI:10.1038/2181135a0