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High Lymphocyte Transformation with Non-haemolytic Streptococcal Product

A VARIETY of antigenic substances can induce generally low percentages of transformation of peripheral blood lymphocytes obtained from specifically sensitive donors into large blast-like cells capable of division. Phytohaemagglutinin, pokeweed extract, streptolysin S , staphylococcal filtrate and an...

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Bibliographic Details
Published in:Nature (London) 1968-08, Vol.219 (5155), p.757-758
Main Authors: TARANTA, A, CUPPARI, G, QUAGLIATA, F
Format: Article
Language:English
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Summary:A VARIETY of antigenic substances can induce generally low percentages of transformation of peripheral blood lymphocytes obtained from specifically sensitive donors into large blast-like cells capable of division. Phytohaemagglutinin, pokeweed extract, streptolysin S , staphylococcal filtrate and antilymphocyte serum are capable of inducing generally higher percentages of transformation in the lymphocytes of all normal subjects, apparently irrespective of previous sensitization (reviewed in ref. 1). Streptolysin S , a haemolytic streptococcal toxin, is of interest because it has been implicated in the pathogenesis of rheumatic fever 2 and lysosome-mediated tissue damage 3 . We report here the induction of a high percentage of transformation of human peripheral blood lymphocytes cultured in vitro with a non-haemolytic streptococcal product.
ISSN:0028-0836
1476-4687
DOI:10.1038/219757a0