Metabolism of Haemoglobin Köln, an Unstable Haemoglobin

HAEMOGLOBIN Köln (α 2 β 2 98met ) (ref. 1) is characterized by increased heat precipitability and abnormal liability to methaemoglobin and Heinz body formation in vitro 2,3 , like other unstable haemoglobins associated with hereditary Heinz body anaemias 4 . Excessive detachment of haem groups takes...

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Bibliographic Details
Published in:Nature (London) 1968-08, Vol.219 (5153), p.494-495
Main Authors: KREIMER-BIRNBAUM, MARTHA, PINKERTON, P. H, BANNERMAN, R. M, HUTCHISON, H. E
Format: Article
Language:English
Subjects:
Carbon Isotopes
Erythrocytes - metabolism
Globins - metabolism
Glutathione - blood
Glycine - metabolism
Hemoglobins, Abnormal - biosynthesis
Hemoglobins, Abnormal - metabolism
Humanities and Social Sciences
Humans
letter
Male
Middle Aged
multidisciplinary
Pyrroles - urine
Science
Science (multidisciplinary)
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Summary:HAEMOGLOBIN Köln (α 2 β 2 98met ) (ref. 1) is characterized by increased heat precipitability and abnormal liability to methaemoglobin and Heinz body formation in vitro 2,3 , like other unstable haemoglobins associated with hereditary Heinz body anaemias 4 . Excessive detachment of haem groups takes place 5 , and may be a source of the “dipyrrolic” urinary pigments found in this syndrome 6,7 .
ISSN:0028-0836
1476-4687
DOI:10.1038/219494a0