Herpesvirus Type 2: Association with Carcinoma of the Cervix

By utilizing the kinetics of neutralization, it was found that an antibody response to type 1 (oral) and type 2 (genital) herpesvirus infection could be independently measured and correlated with type of virus isolated from the patient. The presence of antibodies to type 1 and type 2 herpesvirus was...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1968-09, Vol.161 (3847), p.1255-1256
Main Authors: Rawls, W. E., Tompkins, W. A. F., Figueroa, M. E., Melnick, J. L.
Format: Article
Language:English
Subjects:
Adult
Antibodies
Carcinoma
Cervix uteri
Child
Child, Preschool
Circumcision, Male
Diluents
Epidemiology
Female
Genitalia
Gingivitis - microbiology
Herpesviridae
Herpesviridae - isolation & purification
Herpesviridae Infections - complications
Herpesviridae Infections - immunology
Humans
Infant
Kinetics
Lesions
Lip - microbiology
Male
Middle Aged
Mouth - microbiology
Neutralization Tests
Penis - microbiology
Skin - microbiology
Socioeconomic Factors
Socioeconomics
Stomatitis - microbiology
Uterine Cervical Neoplasms - complications
Uterine Cervical Neoplasms - epidemiology
Uterine Cervical Neoplasms - microbiology
Vagina - microbiology
Viruses
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Summary:By utilizing the kinetics of neutralization, it was found that an antibody response to type 1 (oral) and type 2 (genital) herpesvirus infection could be independently measured and correlated with type of virus isolated from the patient. The presence of antibodies to type 1 and type 2 herpesvirus was examined in patients with carcinoma of the cervix, in matched controls, random controls, and patients with other types of malignancy. Antibodies to type 2 were found with greater frequency in patients with carcinoma of the cervix (83 percent) than in the other groups tested (0 to 20 percent). The data suggest an association of genital herpesvirus and carcinoma of the cervix.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.161.3847.1255