Interferon Induced by Plasmodium berghei

An inhibitor of virus is demonstrable in the serums of mice infected with Plasmodium berghei. The titer of the inhibitor, detectable within 10 hours after injection of parasitized blood, increases rapidly until 30 to 40 hours when it levels off or decreases slightly before reaching a plateau. The fa...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1968-10, Vol.162 (3849), p.123-124
Main Authors: Huang, Kun-Yen, Schultz, Warren W., Gordon, Francis B.
Format: Article
Language:English
Subjects:
Animals
Antiviral Agents
Antivirals
Blood
Blood plasma
Buffers
Erythrocytes
Infections
Interferons
Interferons - biosynthesis
Malaria - blood
Mice
Newcastle disease virus
Parasites
Parasitism
Phosphates
Plasmodium
Sediments
Sodium Chloride
Viruses
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Summary:An inhibitor of virus is demonstrable in the serums of mice infected with Plasmodium berghei. The titer of the inhibitor, detectable within 10 hours after injection of parasitized blood, increases rapidly until 30 to 40 hours when it levels off or decreases slightly before reaching a plateau. The factor that induces production of the antiviral substance is not present in the plasma of the infected blood, and the inhibitor is not detectable in serums of mice injected with nonparasitized mouse erythrocytes. The inhibitor fulfills the essential requirements of an interferon.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.162.3849.123