Diagnosis of type III hyperlipoproteinemia from plasma total cholesterol, triglyceride, and apolipoprotein B

• Published in: Journal of clinical lipidology 2007-08, Vol.1 (4), p.256-263
• Main Authors: Sniderman, Allan, MD, Tremblay, Andre, PhD, Bergeron, Jean, MD, Gagné, Claude, MD, Couture, Patrick, MD, PhD
• Format: Article
• Language: English
• Subjects: Apolipoprotein B; Cardiovascular; Cardiovascular disease; Cholesterol; Clinical diagnosis; Dysbetalipoproteinemia; Triglyceride; Type III hyperlipoproteinemia
• ISSN: 1933-2874; 1876-4789
• DOI: 10.1016/j.jacl.2007.07.006

Objective Our objective was to develop a simple algorithm that could be applied in routine clinical practice to diagnose type III hyperlipoproteinemia based on plasma total cholesterol, triglyceride and apolipoprotein (Apo) B. Methods Analysis of plasma lipid, lipoprotein lipid, and apolipoprotein data from 1771 patients in a tertiary care lipid clinic, from whom all data had been collected prospectively by standardized methods. Of the 1771, based on the Fredrickson classification, 16 had type I hyperlipoproteinemia, 736 type IIa hyperlipoproteinemia, 371 type IIb hyperlipoproteinemia, 38 type III hyperlipoproteinemia, 509 type IV hyperlipoproteinemia, and 101 type V hyperlipoproteinemia. Results Mean plasma ApoB was highest in type IIb (1.53 ± 0.36 g/L), borderline high (1.1 ± 0.23 g/L) in type IV, normal in type III and type V (1.04 ± 0.21 g/L and 0.96 ± 0.40 g/L, respectively) and low in type I (0.48 ± 0.16 g/L). In type III hyperlipoproteinemia, very low–density lipoprotein ApoB (ie, d6.2 and a TG/ApoB ratio of