Dynamic adsorption and desorption behavior of protein on carbonate-containing apatite

A new flow experimental system was employed in order to obtain relevant information about the capability of hydroxyapatite as a drug-delivery carrier in vitro rather than in batch systems. Using our system, we were able to estimate and monitor continuously both the adsorbed and desorbed amounts of p...

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Bibliographic Details
Published in:Journal of the Ceramic Society of Japan 2010/06/01, Vol.118(1378), pp.545-547
Main Authors: KANNO, Toru, INABA, Morito, SENDAI, Toru, TADA, Kiyoshi, HORIUCHI, Jun-ichi, AKAZAWA, Toshiyuki, ITABASHI, Koji
Format: Article
Language:English
Subjects:
Adsorption
Adsorption and desorption behavior of protein
Apatite
Bovine serum albumin
Carbonate ion-containing apatite
Ceramics
Desorption
Drug-delivery carrier
Dynamic tests
Dynamical systems
Dynamics
Flow system
Monitors
Proteins
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Summary:A new flow experimental system was employed in order to obtain relevant information about the capability of hydroxyapatite as a drug-delivery carrier in vitro rather than in batch systems. Using our system, we were able to estimate and monitor continuously both the adsorbed and desorbed amounts of protein and the dynamic adsorption and desorption behavior, indicating that this system is a promising technique for evaluating the drug-release properties of ceramic materials.
ISSN:1882-0743
1348-6535
DOI:10.2109/jcersj2.118.545