Pharmacogenetics and forensic toxicology

Abstract Large inter-individual variability in drug response and toxicity, as well as in drug concentrations after application of the same dosage, can be of genetic, physiological, pathophysiological, or environmental origin. Absorption, distribution and metabolism of a drug and interactions with it...

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Bibliographic Details
Published in:Forensic science international 2010-12, Vol.203 (1), p.53-62
Main Authors: Musshoff, Frank, Stamer, Ulrike M, Madea, Burkhard
Format: Article
Language:English
Subjects:
Analgesics, Opioid - pharmacokinetics
Anticonvulsants - pharmacokinetics
Antidepressants
Antidepressive Agents - pharmacokinetics
Benzodiazepines - pharmacokinetics
Biomarkers
Biomarkers - analysis
Carisoprodol - pharmacokinetics
Codeine
CYP2D6
Cytochrome P-450 Enzyme System - genetics
Drug dosages
Drug therapy
Ethnic Groups - genetics
Fatalities
Forensic medicine
Forensic sciences
Forensic Toxicology
Genes
Genetic Variation
Genetics
Humans
Membrane Transport Proteins - genetics
Metabolism
Metabolites
Molecular Targeted Therapy
Muscle Relaxants, Central - pharmacokinetics
Mutation
N-Methyl-3,4-methylenedioxyamphetamine - pharmacokinetics
P450
Pathology
Pharmacogenetics
Pharmacology
Polymorphism
Postmortem Changes
Toxicology
Tramadol
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Description
Summary:Abstract Large inter-individual variability in drug response and toxicity, as well as in drug concentrations after application of the same dosage, can be of genetic, physiological, pathophysiological, or environmental origin. Absorption, distribution and metabolism of a drug and interactions with its target often are determined by genetic differences. Pharmacokinetic and pharmacodynamic variations can appear at the level of drug metabolizing enzymes (e.g., the cytochrome P450 system), drug transporters, drug targets or other biomarker genes. Pharmacogenetics or toxicogenetics can therefore be relevant in forensic toxicology. This review presents relevant aspects together with some examples from daily routines.
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2010.07.011