Fast, High Resolution Mass Spectrometry Imaging Using a Medipix Pixelated Detector

In mass spectrometry imaging, spatial resolution is pushed to its limits with the use of ion microscope mass spectrometric imaging systems. An ion microscope magnifies and then projects the original spatial distribution of ions from a sample surface onto a position-sensitive detector, while retainin...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Society for Mass Spectrometry 2010-12, Vol.21 (12), p.2023-2030
Main Authors: Jungmann, Julia H., MacAleese, Luke, Buijs, Ronald, Giskes, Frans, de Snaijer, Ad, Visser, Jan, Visschers, Jan, Vrakking, Marc J.J., Heeren, Ron M.A.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Bioinformatics
Biotechnology
Chemistry
Chemistry and Materials Science
Detectors
Exact sciences and technology
Image resolution
Imaging
Instruments, apparatus, components and techniques common to several branches of physics and astronomy
Ion microscopes
Ionization
Ions
Mass spectrometers and related techniques
Mass spectrometry
Materials handling
Metal oxides
Organic Chemistry
Physics
Proteomics
Resolution
Scientific imaging
Secondary ion mass spectrometry
Sensors
Spatial distribution
Spatial resolution
Spectroscopy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In mass spectrometry imaging, spatial resolution is pushed to its limits with the use of ion microscope mass spectrometric imaging systems. An ion microscope magnifies and then projects the original spatial distribution of ions from a sample surface onto a position-sensitive detector, while retaining time-of-flight mass separation capabilities. Here, a new type of position-sensitive detector based on a chevron microchannel plate stack in combination with a 512 × 512 complementary metal-oxide-semiconductor based pixel detector is coupled to an ion microscope. Spatial resolving power better than 6 μm is demonstrated by secondary ion mass spectrometry and 8–10 μm spatial resolving power is achieved with laser desorption ionization. A detailed evaluation of key performance criteria such as spatial resolution, acquisition speed, and data handling is presented. A new, high resolution mass spectrometry imaging detector approach based on a Medipix pixilated detector in combination with an MCP is presented.
ISSN:1044-0305
1879-1123
DOI:10.1016/j.jasms.2010.08.014