Thiopental Pharmacokinetics

A mathematical pharmacokinetic model, including flow limitations, lipid solubility, protein binding, and metabolism, is used to make a priori predictions of the distribution of thiopental in four body regions. Tissue binding is correlated by means of “effective” protein fractions and bovine serum al...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1968-08, Vol.57 (8), p.1346-1351
Main Authors: Bischoff, K.B., Dedrick, R.L.
Format: Article
Language:English
Subjects:
Kinetics
Lipid Metabolism
mathematical-thiopental distribution
Model, mathematical—thiopental distribution
Models, Biological
Pharmacokinetics-thiopental
Protein binding-thiopental
Proteins - metabolism
Thiopental - metabolism
Thiopental-distribution
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Description
Summary:A mathematical pharmacokinetic model, including flow limitations, lipid solubility, protein binding, and metabolism, is used to make a priori predictions of the distribution of thiopental in four body regions. Tissue binding is correlated by means of “effective” protein fractions and bovine serum albumin data. Metabolism is represented by a Michaelis-Menten rate equation. Close agreement with existing experimental data lends confidence in the model as a valuable tool for predictions in a variety of therapeutic situations.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600570814