Ribosidation of 4-Amino-imidazole-5-carboxamide by Escherichia coli

IT has already been shown 1,2 that 4-amino-imidazole-5-carboxamide (I) is a precursor of the purines in E. coli ; a purine-requiring mutant of the organism grows in a medium containing this substance. On the other hand, it has been observed 3,4 that synthetic 4-amino-imidazole-5-carboxamide is littl...

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Bibliographic Details
Published in:Nature (London) 1951-12, Vol.168 (4287), p.1124-1124
Main Authors: BEN-ISHAI, R., BERGMANN, ERNST D., VOLCANI, B. E.
Format: Article
Language:English
Subjects:
Aminoimidazole Carboxamide
Escherichia coli - metabolism
Humanities and Social Sciences
letter
multidisciplinary
Old Medline
Science
Science (multidisciplinary)
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Summary:IT has already been shown 1,2 that 4-amino-imidazole-5-carboxamide (I) is a precursor of the purines in E. coli ; a purine-requiring mutant of the organism grows in a medium containing this substance. On the other hand, it has been observed 3,4 that synthetic 4-amino-imidazole-5-carboxamide is little utilized by a growing culture of E. coli . The following observations will eliminate this apparent discrepancy.
ISSN:0028-0836
1476-4687
DOI:10.1038/1681124a0