Detection of preformed venous thrombi in dogs by means of I-131-labeled antibodies to dog fibrinogen

Dogs with thrombin-induced thrombi received I 131 rabbit antibody to dog fibrinogen and a day later were given antiserum to the rabbit gamma globulin. Scintillation scanning techniques successfully detected the site of thrombosis. Excision of the thrombi and surrounding blood vessels demonstrated de...

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Bibliographic Details
Published in:Circulation research 1965-10, Vol.17 (4), p.322-329
Main Authors: Spar, I L, Goodland, R L, Schwartz, S I
Format: Article
Language:English
Subjects:
Animals
Antibodies
Autoradiography
Dogs
Fibrinogen
gamma-Globulins
Immune Sera
Iodine Radioisotopes
Rabbits
Radionuclide Imaging
Thrombophlebitis - diagnosis
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Summary:Dogs with thrombin-induced thrombi received I 131 rabbit antibody to dog fibrinogen and a day later were given antiserum to the rabbit gamma globulin. Scintillation scanning techniques successfully detected the site of thrombosis. Excision of the thrombi and surrounding blood vessels demonstrated deposition of radioactivity in the lesion. The immunologic removal of the gamma globulin from the circulating blood increased the difference between the radioactivity deposited in the lesion and that present in the blood. This accentuates the lesion and offers potential diagnostic advantage.
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.17.4.322