Brain Transplantation: Prolonged Survival of Brain after Carotid-Jugular Interposition

Six isolated canine brains were successfully transplanted for 6 hours to 2 days to the cervical vasculature of dogs. Viability was shown by electrocortical activity and significant uptakes of oxygen and glucose, with production of carbon dioxide. Cerebral blood flows, temperatures, and pressures of...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1965-11, Vol.150 (3697), p.779-781
Main Authors: White, Robert J., Albin, Maurice S., Locke, George E., Davidson, Eugene
Format: Article
Language:English
Subjects:
Animals
Blood
Blood Gas Analysis
Blood Glucose
Blood Pressure
Blood-Brain Barrier
Body Temperature
Brain Tissue Transplantation
Canines
Carotid arteries
Catheterization
Cerebrovascular Circulation
Dogs
Electroencephalography
Glucose - metabolism
In Vitro Techniques
Jugular vein
Neck
Oxygen
Skull
Transplantation
Transplantation, Homologous
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Summary:Six isolated canine brains were successfully transplanted for 6 hours to 2 days to the cervical vasculature of dogs. Viability was shown by electrocortical activity and significant uptakes of oxygen and glucose, with production of carbon dioxide. Cerebral blood flows, temperatures, and pressures of the cerebral homograft were continuously monitored by way of an implantable recording module.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.150.3697.779