Human Osteosarcomas: Immunologic Evidence Suggesting an Associated Infectious Agent

Immunofluorescent studies have revealed a high incidence of antibodies to osteosarcomas in the serums of patients with this disease and their close associates which react with a common antigen (or antigens) in osteosarcomas. The distribution of these antibodies suggests the association of an infecti...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1968-12, Vol.162 (3859), p.1279-1281
Main Authors: Morton, Donald L., Malmgren, Richard A.
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Blood donation
Cell Transformation, Neoplastic
Etiology
Family members
Fluorescent Antibody Technique
Globulins
Humans
Neoplasia
Oncogenic Viruses
Osteosarcoma
Osteosarcoma - etiology
Osteosarcoma - immunology
Osteosarcoma - microbiology
Sarcoma
Viruses
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Summary:Immunofluorescent studies have revealed a high incidence of antibodies to osteosarcomas in the serums of patients with this disease and their close associates which react with a common antigen (or antigens) in osteosarcomas. The distribution of these antibodies suggests the association of an infectious agent with this neoplasm which is capable of producing unrecognized infections in healthy contacts of these patients.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.162.3859.1279