Effect of the Thiazole Moiety of Thiamine Hydrochloride and Selected Model Compounds on Cyanocobalamin Stability

Data are presented indicating that the thiazole moiety of thiamine hydrochloride, the 3-benzyl derivative of the thiazole moiety, the 3-(4-nitrobenzyl) derivative of the thiazole moiety, and dimethylformamide, a structurally related possible breakdown product of the thiazole moiety, had no adverse e...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1965-07, Vol.54 (7), p.1038-1041
Main Authors: Doerge, Robert F., Ravin, Louis J., Caldwell, Henry C.
Format: Article
Language:English
Subjects:
Chemical Phenomena
Chemistry
Drug Stability
Thiamine
Thiazoles
Vitamin B 12
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Summary:Data are presented indicating that the thiazole moiety of thiamine hydrochloride, the 3-benzyl derivative of the thiazole moiety, the 3-(4-nitrobenzyl) derivative of the thiazole moiety, and dimethylformamide, a structurally related possible breakdown product of the thiazole moiety, had no adverse effect on the stability of cyanocobalamin in aqueous buffered solutions after storage for periods up to 1year at 45°. On the other hand, cyanocobalamin was unstable in the presence of cysteine hydrochloride, another structurally related possible breakdown product of the thiazole moiety, under similar conditions.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600540719