Properties and Uses of Human–Mouse Hybrid Cell Lines

Staged reduction of the chromosome complement of human–mouse hybrid cells has made possible the identification of the chromosome bearing the human gene for thymidine kinase. Effects of human chromosomes on the growth rate of hybrid cells are examined and the possibility of making further chromosomal...

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Bibliographic Details
Published in:Nature (London) 1968-12, Vol.220 (5173), p.1199-1202
Main Authors: MATSUYA, YUTAKA, GREEN, HOWARD, BASILICO, CLAUDIO
Format: Article
Language:English
Subjects:
Anemia, Aplastic - congenital
Animals
Autoradiography
Child
Chromosomes, Human, 16-18
Culture Media
Culture Techniques
Cytogenetics
Fibroblasts - cytology
Humanities and Social Sciences
Humans
Hybridization, Genetic
Lung - embryology
Mice
Molecular Biology
multidisciplinary
Science
Science (multidisciplinary)
Thymidine - metabolism
Thymidine Kinase - metabolism
Tritium
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Summary:Staged reduction of the chromosome complement of human–mouse hybrid cells has made possible the identification of the chromosome bearing the human gene for thymidine kinase. Effects of human chromosomes on the growth rate of hybrid cells are examined and the possibility of making further chromosomal assignments for human autosomal genes is discussed.
ISSN:0028-0836
1476-4687
DOI:10.1038/2201199a0