Determination of Vitamin E in Multivitamin Products by Gas-Liquid Chromatography

The determination of vitamin E in multivitamin preparations has presented considerable analytical problems. Reports on the gas-liquid chromatography of this vitamin have shown that a linear response with concentration can be obtained. This investigation deals primarily with the quantitative analysis...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1968-12, Vol.57 (12), p.2149-2153
Main Authors: Mahn, F.P., Viswanathan, V., Plinton, C., Menyharth, A., Senkowski, B.Z.
Format: Article
Language:English
Subjects:
Capsules
Chromatography, Gas
Dotriacontane-internal standard
GLC-analysis
Methods
Ointments
Powders
Solutions
Tablets
Vitamin D - analysis
Vitamin E - analysis
Vitamin E analysis-multivitamin products
Vitamins - analysis
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Summary:The determination of vitamin E in multivitamin preparations has presented considerable analytical problems. Reports on the gas-liquid chromatography of this vitamin have shown that a linear response with concentration can be obtained. This investigation deals primarily with the quantitative analysis of alpha-tocopheryl acetate utilizing a hydrogen-flame detector. The influence of gas flow rates on detector response and retention times is demonstrated. The conditions for the assay of vitamin E in multivitamin preparations are outlined. A suitable internal standard employed in this study was dotriacontane. The precision of the proposed procedure under the conditions studied is ± 2–3 percent.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600571226