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Determination of Vitamin E in Multivitamin Products by Gas-Liquid Chromatography

The determination of vitamin E in multivitamin preparations has presented considerable analytical problems. Reports on the gas-liquid chromatography of this vitamin have shown that a linear response with concentration can be obtained. This investigation deals primarily with the quantitative analysis...

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Published in:Journal of pharmaceutical sciences 1968-12, Vol.57 (12), p.2149-2153
Main Authors: Mahn, F.P., Viswanathan, V., Plinton, C., Menyharth, A., Senkowski, B.Z.
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Language:English
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cited_by cdi_FETCH-LOGICAL-c4676-a7fd8477ccbfb09a1ad6a92dfd41c4a3a036dab10c3d152b1935406d516669c03
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container_end_page 2153
container_issue 12
container_start_page 2149
container_title Journal of pharmaceutical sciences
container_volume 57
creator Mahn, F.P.
Viswanathan, V.
Plinton, C.
Menyharth, A.
Senkowski, B.Z.
description The determination of vitamin E in multivitamin preparations has presented considerable analytical problems. Reports on the gas-liquid chromatography of this vitamin have shown that a linear response with concentration can be obtained. This investigation deals primarily with the quantitative analysis of alpha-tocopheryl acetate utilizing a hydrogen-flame detector. The influence of gas flow rates on detector response and retention times is demonstrated. The conditions for the assay of vitamin E in multivitamin preparations are outlined. A suitable internal standard employed in this study was dotriacontane. The precision of the proposed procedure under the conditions studied is ± 2–3 percent.
doi_str_mv 10.1002/jps.2600571226
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ispartof Journal of pharmaceutical sciences, 1968-12, Vol.57 (12), p.2149-2153
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source Wiley Online Library
subjects Capsules
Chromatography, Gas
Dotriacontane-internal standard
GLC-analysis
Methods
Ointments
Powders
Solutions
Tablets
Vitamin D - analysis
Vitamin E - analysis
Vitamin E analysis-multivitamin products
Vitamins - analysis
title Determination of Vitamin E in Multivitamin Products by Gas-Liquid Chromatography
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