Hemophagocytic lymphohistiocytosis associated with precursor B acute lymphoblastic leukemia

We report a case of a child with precursor‐B acute lymphoblastic leukemia (ALL) who experienced refractory thrombocytopenia and massive splenomegaly during standard induction chemotherapy. He was diagnosed with hemophatocytic lymphohistiocytosis (HLH) during induction. Clinical and laboratory evalua...

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Bibliographic Details
Published in:Pediatric blood & cancer 2011-04, Vol.56 (4), p.658-660
Main Authors: Kelly, Caitlin, Salvi, Sharad, McClain, Kenneth, Hayani, Ammar
Format: Article
Language:English
Subjects:
Acute lymphatic leukemia
acute lymphoblastic leukemia
Blood
bone marrow transplantation
Cancer
Case reports
Chemotherapy
Child
hemophagocytic lymphohistiocytosis
Histiocytosis
Humans
Lymphocytosis
Lymphohistiocytosis, Hemophagocytic - complications
Lymphohistiocytosis, Hemophagocytic - drug therapy
Male
Pancytopenia
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - complications
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Remission
Splenomegaly
stem cell transplantation
Thrombocytopenia
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Summary:We report a case of a child with precursor‐B acute lymphoblastic leukemia (ALL) who experienced refractory thrombocytopenia and massive splenomegaly during standard induction chemotherapy. He was diagnosed with hemophatocytic lymphohistiocytosis (HLH) during induction. Clinical and laboratory evaluation showed no evidence of infectious cause to HLH. Pancytopenia and HLH persisted after consolidation therapy even with remission from leukemia. After failure to control HLH with ALL‐directed therapy and HLH‐directed therapy, the patient underwent unrelated donor hematopoietic stem cell transplantation 8 months after diagnosis. He is 34 months post‐transplant and in remission from leukemia and HLH. Pediatr Blood Cancer 2011;56:658–660. © 2010 Wiley‐Liss, Inc.
ISSN:1545-5009
1545-5017
1545-5017
DOI:10.1002/pbc.22688