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Hemophagocytic lymphohistiocytosis associated with precursor B acute lymphoblastic leukemia
We report a case of a child with precursor‐B acute lymphoblastic leukemia (ALL) who experienced refractory thrombocytopenia and massive splenomegaly during standard induction chemotherapy. He was diagnosed with hemophatocytic lymphohistiocytosis (HLH) during induction. Clinical and laboratory evalua...
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| Published in: | Pediatric blood & cancer 2011-04, Vol.56 (4), p.658-660 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c3958-6e0a3de2b0bcfb64a66007d7db2e289cdc66c5fa2debf61a12d1ac9114d7f8b63 |
| container_end_page | 660 |
| container_issue | 4 |
| container_start_page | 658 |
| container_title | Pediatric blood & cancer |
| container_volume | 56 |
| creator | Kelly, Caitlin Salvi, Sharad McClain, Kenneth Hayani, Ammar |
| description | We report a case of a child with precursor‐B acute lymphoblastic leukemia (ALL) who experienced refractory thrombocytopenia and massive splenomegaly during standard induction chemotherapy. He was diagnosed with hemophatocytic lymphohistiocytosis (HLH) during induction. Clinical and laboratory evaluation showed no evidence of infectious cause to HLH. Pancytopenia and HLH persisted after consolidation therapy even with remission from leukemia. After failure to control HLH with ALL‐directed therapy and HLH‐directed therapy, the patient underwent unrelated donor hematopoietic stem cell transplantation 8 months after diagnosis. He is 34 months post‐transplant and in remission from leukemia and HLH. Pediatr Blood Cancer 2011;56:658–660. © 2010 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/pbc.22688 |
| format | article |
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He was diagnosed with hemophatocytic lymphohistiocytosis (HLH) during induction. Clinical and laboratory evaluation showed no evidence of infectious cause to HLH. Pancytopenia and HLH persisted after consolidation therapy even with remission from leukemia. After failure to control HLH with ALL‐directed therapy and HLH‐directed therapy, the patient underwent unrelated donor hematopoietic stem cell transplantation 8 months after diagnosis. He is 34 months post‐transplant and in remission from leukemia and HLH. Pediatr Blood Cancer 2011;56:658–660. © 2010 Wiley‐Liss, Inc.</description><identifier>ISSN: 1545-5009</identifier><identifier>ISSN: 1545-5017</identifier><identifier>EISSN: 1545-5017</identifier><identifier>DOI: 10.1002/pbc.22688</identifier><identifier>PMID: 21298755</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Acute lymphatic leukemia ; acute lymphoblastic leukemia ; Blood ; bone marrow transplantation ; Cancer ; Case reports ; Chemotherapy ; Child ; hemophagocytic lymphohistiocytosis ; Histiocytosis ; Humans ; Lymphocytosis ; Lymphohistiocytosis, Hemophagocytic - complications ; Lymphohistiocytosis, Hemophagocytic - drug therapy ; Male ; Pancytopenia ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - complications ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy ; Remission ; Splenomegaly ; stem cell transplantation ; Thrombocytopenia</subject><ispartof>Pediatric blood & cancer, 2011-04, Vol.56 (4), p.658-660</ispartof><rights>Copyright © 2010 Wiley‐Liss, Inc.</rights><rights>Copyright © 2010 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3958-6e0a3de2b0bcfb64a66007d7db2e289cdc66c5fa2debf61a12d1ac9114d7f8b63</citedby><cites>FETCH-LOGICAL-c3958-6e0a3de2b0bcfb64a66007d7db2e289cdc66c5fa2debf61a12d1ac9114d7f8b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21298755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kelly, Caitlin</creatorcontrib><creatorcontrib>Salvi, Sharad</creatorcontrib><creatorcontrib>McClain, Kenneth</creatorcontrib><creatorcontrib>Hayani, Ammar</creatorcontrib><title>Hemophagocytic lymphohistiocytosis associated with precursor B acute lymphoblastic leukemia</title><title>Pediatric blood & cancer</title><addtitle>Pediatr. Blood Cancer</addtitle><description>We report a case of a child with precursor‐B acute lymphoblastic leukemia (ALL) who experienced refractory thrombocytopenia and massive splenomegaly during standard induction chemotherapy. He was diagnosed with hemophatocytic lymphohistiocytosis (HLH) during induction. Clinical and laboratory evaluation showed no evidence of infectious cause to HLH. Pancytopenia and HLH persisted after consolidation therapy even with remission from leukemia. After failure to control HLH with ALL‐directed therapy and HLH‐directed therapy, the patient underwent unrelated donor hematopoietic stem cell transplantation 8 months after diagnosis. He is 34 months post‐transplant and in remission from leukemia and HLH. Pediatr Blood Cancer 2011;56:658–660. © 2010 Wiley‐Liss, Inc.</description><subject>Acute lymphatic leukemia</subject><subject>acute lymphoblastic leukemia</subject><subject>Blood</subject><subject>bone marrow transplantation</subject><subject>Cancer</subject><subject>Case reports</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>hemophagocytic lymphohistiocytosis</subject><subject>Histiocytosis</subject><subject>Humans</subject><subject>Lymphocytosis</subject><subject>Lymphohistiocytosis, Hemophagocytic - complications</subject><subject>Lymphohistiocytosis, Hemophagocytic - drug therapy</subject><subject>Male</subject><subject>Pancytopenia</subject><subject>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - complications</subject><subject>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</subject><subject>Remission</subject><subject>Splenomegaly</subject><subject>stem cell transplantation</subject><subject>Thrombocytopenia</subject><issn>1545-5009</issn><issn>1545-5017</issn><issn>1545-5017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp90ctO4zAYBWALMeK-4AVQdgyLgO3EjrOkFRQ0MIM0g5BgYfnyhxoSnLETQd-elJbuYGXL-s5ZHCO0T_AxwZietNocU8qFWENbhOUsZZgU66s7LjfRdoxPA-WYiQ20SQktRcHYFnq4gMa3U_XozaxzJqlnTTv1Uxc7N3_x0cVExeiNUx3Y5NV106QNYPoQfUhGiTJ9B8uUrlX86ID-GRqndtGPStUR9pbnDro9P_s3vkiv_kwux6dXqclKJlIOWGUWqMbaVJrninOMC1tYTYGK0ljDuWGVohZ0xYki1BJlSkJyW1RC82wHHS562-D_9xA72bhooK7VC_g-SsEw4yRnc_nzW0kwxYLlGWcDPVpQE3yMASrZBteoMBuQnK8uh9Xlx-qDPVjW9roBu5KfMw_gZAFeXQ2zr5vkzWj8WZkuEsNPwNsqocKz5EVWMHn3eyLH1_d_z6-LX3KSvQPaSJ2t</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Kelly, Caitlin</creator><creator>Salvi, Sharad</creator><creator>McClain, Kenneth</creator><creator>Hayani, Ammar</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201104</creationdate><title>Hemophagocytic lymphohistiocytosis associated with precursor B acute lymphoblastic leukemia</title><author>Kelly, Caitlin ; Salvi, Sharad ; McClain, Kenneth ; Hayani, Ammar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3958-6e0a3de2b0bcfb64a66007d7db2e289cdc66c5fa2debf61a12d1ac9114d7f8b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acute lymphatic leukemia</topic><topic>acute lymphoblastic leukemia</topic><topic>Blood</topic><topic>bone marrow transplantation</topic><topic>Cancer</topic><topic>Case reports</topic><topic>Chemotherapy</topic><topic>Child</topic><topic>hemophagocytic lymphohistiocytosis</topic><topic>Histiocytosis</topic><topic>Humans</topic><topic>Lymphocytosis</topic><topic>Lymphohistiocytosis, Hemophagocytic - complications</topic><topic>Lymphohistiocytosis, Hemophagocytic - drug therapy</topic><topic>Male</topic><topic>Pancytopenia</topic><topic>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - complications</topic><topic>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</topic><topic>Remission</topic><topic>Splenomegaly</topic><topic>stem cell transplantation</topic><topic>Thrombocytopenia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kelly, Caitlin</creatorcontrib><creatorcontrib>Salvi, Sharad</creatorcontrib><creatorcontrib>McClain, Kenneth</creatorcontrib><creatorcontrib>Hayani, Ammar</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric blood & cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kelly, Caitlin</au><au>Salvi, Sharad</au><au>McClain, Kenneth</au><au>Hayani, Ammar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemophagocytic lymphohistiocytosis associated with precursor B acute lymphoblastic leukemia</atitle><jtitle>Pediatric blood & cancer</jtitle><addtitle>Pediatr. Blood Cancer</addtitle><date>2011-04</date><risdate>2011</risdate><volume>56</volume><issue>4</issue><spage>658</spage><epage>660</epage><pages>658-660</pages><issn>1545-5009</issn><issn>1545-5017</issn><eissn>1545-5017</eissn><abstract>We report a case of a child with precursor‐B acute lymphoblastic leukemia (ALL) who experienced refractory thrombocytopenia and massive splenomegaly during standard induction chemotherapy. He was diagnosed with hemophatocytic lymphohistiocytosis (HLH) during induction. Clinical and laboratory evaluation showed no evidence of infectious cause to HLH. Pancytopenia and HLH persisted after consolidation therapy even with remission from leukemia. After failure to control HLH with ALL‐directed therapy and HLH‐directed therapy, the patient underwent unrelated donor hematopoietic stem cell transplantation 8 months after diagnosis. He is 34 months post‐transplant and in remission from leukemia and HLH. Pediatr Blood Cancer 2011;56:658–660. © 2010 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21298755</pmid><doi>10.1002/pbc.22688</doi><tpages>3</tpages></addata></record> |
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| ispartof | Pediatric blood & cancer, 2011-04, Vol.56 (4), p.658-660 |
| issn | 1545-5009 1545-5017 1545-5017 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Acute lymphatic leukemia acute lymphoblastic leukemia Blood bone marrow transplantation Cancer Case reports Chemotherapy Child hemophagocytic lymphohistiocytosis Histiocytosis Humans Lymphocytosis Lymphohistiocytosis, Hemophagocytic - complications Lymphohistiocytosis, Hemophagocytic - drug therapy Male Pancytopenia Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Remission Splenomegaly stem cell transplantation Thrombocytopenia |
| title | Hemophagocytic lymphohistiocytosis associated with precursor B acute lymphoblastic leukemia |
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