Associations between nutritional status, weight loss, radiotherapy treatment toxicity and treatment outcomes in gastrointestinal cancer patients

Summary Background & aims Patients with gastrointestinal cancers are susceptible to nutritional deterioration which may be compounded by radiotherapy treatment toxicities. This study aimed to determine whether nutritional status at radiotherapy commencement or changes in nutritional status throu...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2011-02, Vol.30 (1), p.92-98
Main Authors: Hill, Amanda, Kiss, Nicole, Hodgson, Belinda, Crowe, Timothy C, Walsh, Adam D
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gastroenterology and Hepatology
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal cancer
Gastrointestinal Neoplasms - complications
Gastrointestinal Neoplasms - radiotherapy
Humans
Male
Malnutrition - complications
Medical sciences
Middle Aged
Nutritional status
Nutritional Status - radiation effects
Prospective Studies
Radiotherapy
Retrospective Studies
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Toxicity
Treatment Outcome
Tumors
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Weight Loss
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Summary:Summary Background & aims Patients with gastrointestinal cancers are susceptible to nutritional deterioration which may be compounded by radiotherapy treatment toxicities. This study aimed to determine whether nutritional status at radiotherapy commencement or changes in nutritional status throughout radiotherapy were associated with treatment toxicity and outcomes in gastrointestinal cancer patients. Methods Seventy-three gastrointestinal cancer patients receiving curative radiotherapy underwent medical record audits assessing body weight, radiotherapy toxicity, unplanned treatment breaks or hospital admissions and completion of prescribed treatment/s. Nutritional status was assessed in a subset of patients ( n  = 11) using the Patient-Generated Subjective Global Assessment tool. Results Seventy-five percent of patients lost weight throughout radiotherapy. Weight loss was significantly greater in patients experiencing unplanned radiotherapy breaks (−3.1% vs −1.6%, p  
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2010.07.015