Reversal of hypercoagulability with hydroxyethyl starch during transplantation: a case series

Abstract During transplant surgery, clot formation resulting in life-threatening thromboembolic phenomena or graft loss may be a consequence unless close monitoring of coagulation and anticoagulation treatment is instituted in a timely manner. Three cases with a hypercoagulable state, as determined...

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Bibliographic Details
Published in:Journal of clinical anesthesia 2011-02, Vol.23 (1), p.61-65
Main Authors: Fukazawa, Kyota, MD, Pretto, Ernesto A., MD, MPH
Format: Article
Language:English
Subjects:
Adult
Anesthesia
Anesthesia & Perioperative Care
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood platelets
Catheters
Creatinine
Diabetes Mellitus, Type 1 - surgery
Fentanyl
Humans
Hydroxyethyl starch
Hydroxyethyl Starch Derivatives - administration & dosage
Hydroxyethyl Starch Derivatives - therapeutic use
Hypercoagulable state
Infusions, Intravenous
Intestines - transplantation
Intraoperative Complications - drug therapy
Ischemia
Kidney diseases
Kidney Failure, Chronic - surgery
Kidney Transplantation - adverse effects
Kidney transplants
Male
Medical sciences
Middle Aged
Monitoring, Intraoperative
Mortality
Organ Transplantation - adverse effects
Pain Medicine
Pancreas Transplantation - adverse effects
Pancreas transplants
Patients
Plasma Substitutes - administration & dosage
Plasma Substitutes - therapeutic use
Postoperative period
Stroke
Surgery
Thrombelastography
Thromboembolism
Thrombophilia - drug therapy
Thrombosis
Transplantation
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Description
Summary:Abstract During transplant surgery, clot formation resulting in life-threatening thromboembolic phenomena or graft loss may be a consequence unless close monitoring of coagulation and anticoagulation treatment is instituted in a timely manner. Three cases with a hypercoagulable state, as determined by thrombelastography at the time of surgery, but whose hypercoagulation was gradually attenuated with hydroxyethyl starch infusion during transplantation, are presented.
ISSN:0952-8180
1873-4529
DOI:10.1016/j.jclinane.2009.10.021