Unexpected role of nucleoporins in coordination of cell cycle progression

Many human cancers have irregular chromosome content, a condition known as aneuploidy. Several nuclear pore proteins (nucleoporins/Nups) that mediate transport of RNA or macromolecules into and out of the nucleus have been implicated in mitosis. These nucleoporins are involved in molecular networks...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2011-02, Vol.10 (3), p.425-433
Main Authors: Nakano, Hiroshi, Wang, Wei, Hashizume, Chieko, Funasaka, Tatsuyoshi, Sato, Hiroshi, Wong, Richard W.
Format: Article
Language:English
Subjects:
Active Transport, Cell Nucleus
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cell Cycle
Cycle
Humans
Landes
Mitosis
Models, Biological
Nuclear Pore - chemistry
Nuclear Pore - metabolism
Nuclear Pore - physiology
Nuclear Pore Complex Proteins - chemistry
Nuclear Pore Complex Proteins - physiology
Organogenesis
Proteins
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Summary:Many human cancers have irregular chromosome content, a condition known as aneuploidy. Several nuclear pore proteins (nucleoporins/Nups) that mediate transport of RNA or macromolecules into and out of the nucleus have been implicated in mitosis. These nucleoporins are involved in molecular networks that function in a variety of mitotic processes, including chromosome condensation, sister chromatid cohesion, kinetochore assembly and spindle formation. An alteration in the concentration of Nups inside cells often causes aneuploidy. In this review, we discuss this sprouting area and the possible functions of Nups during mitosis.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.10.3.14721