Reticuloendothelial Blockade: Effect of Puromycin on Opsonin-Dependent Recovery

Reticuloendothelial blockade induced by the administration of a gelatinized "reticuloendothelial test lipid emulsion" is due to a loss of opsonic activity in the plasma. Recovery from blockade, which is associated with restoration of plasma opsonins, was inhibited by the administration of...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1968-11, Vol.162 (3853), p.565-567
Main Authors: Pisano, J. C., Patterson, J. T., Di Luzio, N. R.
Format: Article
Language:English
Subjects:
Animals
Depression, Chemical
Emulsions
In Vitro Techniques
Lipids
Lipids - pharmacology
Liver
Liver - cytology
Macrophages
Male
Mononuclear Phagocyte System - drug effects
Opsonin Proteins - biosynthesis
Opsonin Proteins - physiology
Opsonins
Phagocytosis
Puromycin - pharmacology
Rats
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Summary:Reticuloendothelial blockade induced by the administration of a gelatinized "reticuloendothelial test lipid emulsion" is due to a loss of opsonic activity in the plasma. Recovery from blockade, which is associated with restoration of plasma opsonins, was inhibited by the administration of puromycin. The effect of puromycin appears to be mediated by inhibition of opsonin formation rather than a puromycin-induced macrophage defect in phagocytosis.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.162.3853.565